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Volume 26, Number 8—August 2020
Dispatch

Atypical Pathogenicity of Avian Influenza (H3N1) Virus Involved in Outbreak, Belgium, 2019

Mieke SteenselsComments to Author , Philippe Gelaude, Steven Van Borm, Thierry Van Den Berg, Mickaël Cargnel, Virginie Roupie, Fabienne Rauw, and Bénédicte Lambrecht
Author affiliations: Sciensano, Brussels, Belgium (M. Steensels, S. Van Borm, T. Van Den Berg, M. Cargnel, V. Roupie, F. Rauw, B. Lambrecht); Animal Health Vlaanderen, Torhout, Belgium (P. Gelaude)

Main Article

Table 2

Seroconversion of sentinel birds and birds infected with A/Gallus gallus/Belgium/3497_0001/2019 (H3N1) virus

Bird 9 dpi
14 dpi
21 dpi
ELISA-NP†
HI‡
ELISA-NP†
HI‡
ELISA-NP†
HI‡

S/N, %
IR
log 2
IR

S/N, %
IR
log 2
IR

S/N, %
IR
log 2
IR
Infected 1 4.3 + 6 + 4.8 + 10 + 5.5 + 8 +
Infected 2 5.0 + 6 + 5.6 + 9 + 4.7 + 9 +
Infected 3 5.8 + 6 + 4.8 + 9 + 4.3 + 9 +
Infected 4 10.2 + 3 9.0 + 3 12.6 + 3
Infected 5§ NA NA NA NA NA NA NA NA NA NA NA
Infected 6§ NA NA NA NA NA NA NA NA NA NA NA
Average (SD)
6.3 ±2.6
5.3 ±1.5

6.0 ±2.0
7.8 ±3.2

6.8 ±3.9
7.3 ±2.9
Sentinel 1 17.6 + 2 5.3 + 7 + 4.8 + 9 +
Sentinel 2 5.9 + 2 4.9 + 7 + 4.8 + 7 +
Sentinel 3 7.7 + 2 4.9 + 6 + 4.6 + 8 +
Sentinel 4§ NA NA NA NA NA NA NA NA NA NA NA
Sentinel 5 5.7 + 3 4.7 + 8 + 4.8 + 9 +
Sentinel 6 5.6 + 2 4.4 + 7 + 5.5 + 8 +
Average (SD) 8.5 ±5.1
2.2 ±0.4
4.8 ±0.3
7.0 ±0.7
4.9 ±0.4
8.2 ± 0.8

*dpi, days postinfection; ELISA-NP, nucleoprotein competition ELISA; HI, hemagglutination inhibition; IR, immune response; NA, not applicable because of bird death; S/N, signal-to-noise ratio; +, positive immune response; –, negative immune response.
†(IDVet, https://www.id-vet.com/). ELISA data are presented as the percentage of competition detected, the S/N.
‡HI test with the homologous H3N1 antigen. HI data are presented as log2 of the HI titer.

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Page created: June 12, 2020
Page updated: July 18, 2020
Page reviewed: July 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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