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Volume 26, Number 8—August 2020

Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France

Marie JaspardComments to Author , Nathalie Butel, Najoua El Helali, Dhiba Marigot-Outtandy, Helene Guillot, Gilles Peytavin, Nicolas Veziris, Bahram Bodaghi, Philippe Flandre, Gregoire Petitjean, Eric Caumes, and Valerie Pourcher
Author affiliations: Sorbonne Université, Paris, France (M. Jaspard, H. Guillot, N. Veziris, B. Bodaghi, E. Caumes, V. Pourcher); Assistance Publique–Hôpitaux de Paris, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Paris (M. Jaspard, H. Guillot, E. Caumes, V. Pourcher); Assistance Publique – Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris (N. Butel, B. Bodaghi); Groupe Hospitalier Paris Saint Joseph, Paris (N. El Helali, G. Petitjean); Bligny Medical Center, Briis sous Forges, France (D. Marigot-Outtandy); Assistance Publique–Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris (G. Peytavin); Université Paris Diderot, Sorbonne Paris Cité, Paris (G. Peytavin); Assistance Publique–Hôpitaux de Paris, Hôpitaux Universitaires de l’Est Parisien, Paris (N. Veziris); Institut Pierre Louis Institute d’Épidémiologie et de Santé Publique, Paris (P. Flandre, E. Caumes, V. Pourcher)

Main Article

Table 5

Association between clinical and confirmed peripheral and optical neuropathy and patient characteristics among 57 patients with multidrug-resistant tuberculosis, Pitié-Salpêtrière Hospital, Paris, France, 2011–2016*

Characteristic Clinical neuropathy
Confirmed neuropathy
Value p value* Value p value*
Age, OR (95% CI)† 1.83 (0.9–3.7) 0.09 1.66 (0.8–3.3) 0.14
Immunosuppression treatment, OR (95% CI) 0.91 (0.3–2.7) 0.98 2.1 (0.7–6.2) 0.18
History of intravenous drug use, OR (95% CI) 0.43 (0.5–4.9) 0.43 1.79 (0.6–5.4) 0.30
Opioid substitution therapy, OR (95% CI) 1.6 (0.4–6.1) 0.49 1.92 (0.5–7) 0.32
Albumin, g/L 0.81 (0.4–1.8) 0.61 1.01 (0.5–2.2) 0.98
Linezolid treatment duration, mo 0.47 (0.2–1.2) 0.10 1.11 (0.5–2.7) 0.82
Culture conversion, d 0.93 (0.8–1.1) 0.35 1.15 (0.9–1.4) 0.21
Trough linezolid concentration >2 mg/L 2.07 (0.6–7.3) 0.26 0.83 (0.3–2.7) 0.76

*p values from univariate logistic models. OR, odds ratio.
†Risk based on age increase by 10-y intervals.

Main Article

Page created: June 12, 2020
Page updated: July 17, 2020
Page reviewed: July 17, 2020
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