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Volume 26, Number 8—August 2020
Dispatch

Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018

Lovlesh Thakur, Kiran K. Singh, Hemant R. Kushwaha, Sudarshan K. Sharma, Vinay Shankar, Ajeet Negi, Ghanshyam Verma, Sandhya Kumari, Aklank Jain, and Manju JainComments to Author 
Author affiliations: Central University of Punjab, Bathinda, India (L. Thakur, K.K. Singh, A. Jain, M. Jain); Jawaharlal Nehru University, New Delhi, India (H.R. Kushwaha); Indira Gandhi Medical College, Shimla, India (S.K. Sharma, A. Negi, G. Verma, S. Kumari); Maharishi Markandeshwar Medical College and Hospital, Kumarhatti-Solan, India (V. Shankar)

Main Article

Table 1

Standard Leishmania strains used in ITS1-based microsatellite polymorphism and phylogenetic analysis of cutaneous leishmaniasis isolates, Himachal Pradesh, India, 2014–2018*

Standard Leishmania strains (place of origin) WHO code Genbank accession no. Zymodeme Disease form Strain type† ITS1 polymorphic microsatellite stretches (nucleotide position, bp)
Poly C
(24–39) Poly A
(24–39) Poly TA
(61–76) Poly A (124–134)
VL- and CL-causing L. infantum and L. donovani parasite strains  
L. infantum (Tunisia) MHOM/TN/80/IPT1 AJ000289 MON-1 VL A 3 6 4 8
L. donovani (India) MHOM/IN/00/DEVI AJ634376 MON-2 VL H 2 8 5 7
L. donovani 
(Sri Lanka) MHOM/LK/2002/
L60c AM901447 MON-37 CL ND 2 8 5 7
L. donovani 
(Bangladesh) ND KT921417 ND VL ND 2 8 5 7
L. donovani (Kenya) MHOM/KE/85/
NLB323 AJ000297 MON-37 VL G 2 8 5 7
L. donovani (Sudan) MHOM/SD/75/
LV139 AJ000291 ND CL E 2 8 6 8
MHOM/SD/93/9S AJ634372 MON-18 VL F 2 9 5 7
L. donovani (Ethiopia) MHOM/ET/67/HU3 AJ634373 MON-18 VL F 2 9 5 7
L. donovani (China) MHOM/CN/00/
Wangjie1 AJ000294 MON-35 VL C 3 6 4 7
L. donovani 
(HP, India) MHOM/IN/83/
CHANDIGARH AM901449 MON-37 VL ND 2 8 2, TAA, 3 7
L. donovani (Bhutan)
 Trashigang1 JQ730001 ND VL ND 2 8 2, TAA, 3 8
Samtse1
 JQ730002
 ND
 VL
 ND
 2
 9
 2, TAA, 3
 8
CL-causing L. donovani isolates from Himachal Pradesh‡
HPCL22 – MG982955 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL27 – MG982958 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL28 – MG982959 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL32 – MG982963 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL42 – MG982972 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL45 – MG982975 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL47 – MG982977 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL49 – MG982978 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL52 – MG982981 ND CL ND Heterogeneous 2, TAA, 3 8
HPCL55
 –
 MG982983
 ND
 CL
 ND
 Heterogeneous
 2, TAA, 3
 8
CL-causing standard WHO Leishmania species
L. major MHOM/SU/73/
5ASKH AJ000310 MON-4 CL ND 4 6 6 6
L. tropica MHOM/SU/60/OD EU326226 LON-7 CL ND 4 9 1, TTA, 2 3,C,4A
L. mexicana MHOM/MX/85/
SOLIS AJ000313 MON-152 CL ND 2 8 1, 3,C,7A
L. braziliensis MHOM/BR/00/
LTB300 FN398338 MON-166 CL ND 2 6 1 5
L. amazonensis MHOM/BR/73/
M2269 HG512964 MON-132 CL ND 2 7 1 3,C,6A

*CL, cutaneous leishmaniasis; HP, Himachal Pradesh; ITS1, internal transcribed spacer 1; ND, not determined; VL, visceral leishmaniasis; WHO, World Health Organization.
†ITS sequences strain type according to Kuhls et al. (13).
‡These species represent 10/44 samples used in polymorphic microsatellite analysis.

Main Article

Page created: June 10, 2020
Page updated: July 18, 2020
Page reviewed: July 18, 2020
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