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Volume 26, Number 8—August 2020
Dispatch

Genotypic Heterogeneity of Orientia tsutsugamushi in Scrub Typhus Patients and Thrombocytopenia Syndrome Co-infection, Myanmar

Aye Marlar Win1, Yen Thi Hai Nguyen1, Yuri Kim1, Na-Young Ha, Jun-Gu Kang, Hongil Kim, Bo San, Okkar Kyaw, Wah Win Htike, Dong-Ok Choi, Keun-Hwa Lee2Comments to Author , and Nam-Hyuk Cho2Comments to Author 
Author affiliations: University of Medicine 1, Yangon, Myanmar (A.M. Win, O. Kyaw, W.W. Htike); Seoul National; University College of Medicine, Seoul, South Korea (Y.T.H. Nguyen, Y. Kim, N.-Y. Ha, J.-G. Kang, H. Kim, N.-H. Cho); Private practitioner, Sagaing, Myanmar (B. San); Bore Da Biotech, Seongnam, South Korea (D.-O. Choi); Hanyang University College of Medicine, Seoul (K.-H. Lee); Seoul National University Medical Research Center and Bundang Hospital, Seoul (N.-H. Cho)

Main Article

Table

Baseline characteristics and summary of serologic and molecular diagnosis of suspected scrub typhus patients enrolled in study of genotypic heterogeneity of Orientia tsutsugamushi, Myanmar

Category Value
Age
Age, y mean ± SD 27.0 ± 19.8
Age distribution, y
≤10 38 (25.0)
11–20 38 (25.0)
21–30 23 (15.1)
31–40 10 (6.6)
41–50 17 (11.0)
51–60 16 (10.5)
≥61
 10 (6.6)
Sex ratio, M:F (% male)
 93/59 (61.2)
Clinical variables
Fever duration, d, mean ±SD 6.1 ± 2.9
Eschar 144 (94.7)
Rash 3 (2.0)
Myalgia
 25 (20)
Method of diagnosis of scrub typhus
ICT 41/128 (32.0)
TSA56 IgG 36/128 (28.1)
ScaA IgG 25/128 (19.5)
IFA 138/152 (90.8)
O. tsutsugamushi IgG 119/152 (78.3)
O. tsutsugamushi IgM 90/152 (59.2)
PCR (tsa56)
 9/152 (5.9)
Method of diagnosis of SFTSV
RT-PCR 5/152 (3.3)

*Values are no. (%) patients or no. patients/no. tested (%) except as indicated. ICT, immunochromatography test; IFA, indirect immunofluorescence assay; RT-PCR, reverse transcription PCR; SFTSV, severe fever with thrombosis syndrome virus.

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

Page created: April 18, 2020
Page updated: July 19, 2020
Page reviewed: July 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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