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Volume 26, Number 8—August 2020

Genotypic Heterogeneity of Orientia tsutsugamushi in Scrub Typhus Patients and Thrombocytopenia Syndrome Co-infection, Myanmar

Aye Marlar Win1, Yen Thi Hai Nguyen1, Yuri Kim1, Na-Young Ha, Jun-Gu Kang, Hongil Kim, Bo San, Okkar Kyaw, Wah Win Htike, Dong-Ok Choi, Keun-Hwa Lee2Comments to Author , and Nam-Hyuk Cho2Comments to Author 
Author affiliations: University of Medicine 1, Yangon, Myanmar (A.M. Win, O. Kyaw, W.W. Htike); Seoul National; University College of Medicine, Seoul, South Korea (Y.T.H. Nguyen, Y. Kim, N.-Y. Ha, J.-G. Kang, H. Kim, N.-H. Cho); Private practitioner, Sagaing, Myanmar (B. San); Bore Da Biotech, Seongnam, South Korea (D.-O. Choi); Hanyang University College of Medicine, Seoul (K.-H. Lee); Seoul National University Medical Research Center and Bundang Hospital, Seoul (N.-H. Cho)

Main Article


Baseline characteristics and summary of serologic and molecular diagnosis of suspected scrub typhus patients enrolled in study of genotypic heterogeneity of Orientia tsutsugamushi, Myanmar

Category Value
Age, y mean ± SD 27.0 ± 19.8
Age distribution, y
≤10 38 (25.0)
11–20 38 (25.0)
21–30 23 (15.1)
31–40 10 (6.6)
41–50 17 (11.0)
51–60 16 (10.5)
10 (6.6)
Sex ratio, M:F (% male)
93/59 (61.2)
Clinical variables
Fever duration, d, mean ±SD 6.1 ± 2.9
Eschar 144 (94.7)
Rash 3 (2.0)
25 (20)
Method of diagnosis of scrub typhus
ICT 41/128 (32.0)
TSA56 IgG 36/128 (28.1)
ScaA IgG 25/128 (19.5)
IFA 138/152 (90.8)
O. tsutsugamushi IgG 119/152 (78.3)
O. tsutsugamushi IgM 90/152 (59.2)
PCR (tsa56)
9/152 (5.9)
Method of diagnosis of SFTSV
RT-PCR 5/152 (3.3)

*Values are no. (%) patients or no. patients/no. tested (%) except as indicated. ICT, immunochromatography test; IFA, indirect immunofluorescence assay; RT-PCR, reverse transcription PCR; SFTSV, severe fever with thrombosis syndrome virus.

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

Page created: April 18, 2020
Page updated: July 19, 2020
Page reviewed: July 19, 2020
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