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Volume 26, Number 8—August 2020
Dispatch

Evolution and Antigenic Drift of Influenza A (H7N9) Viruses, China, 2017–2019

Jiahao Zhang1, Hejia Ye1, Huanan Li1, Kaixiong Ma, Weihong Qiu, Yiqun Chen, Ziwen Qiu, Bo Li, Weixin Jia, Zhaoping Liang, Ming LiaoComments to Author , and Wenbao QiComments to Author 
Author affiliations: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China (J. Zhang, H. Li, K. Ma, Y. Chen, Z. Qiu, B. Li, W. Jia, M. Liao, W. Qi); National Avian Influenza Para-Reference Laboratory, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Guangzhou (J. Zhang, H. Li, W. Jia, M. Liao, W. Qi); Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, National Development and Reform Commission, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); Guangzhou South China Biological Medicine Co., Ltd, Guangzhou (H. Ye, W. Qiu, Z. Liang); Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou (W. Jia, M. Liao, W. Qi)

Main Article

Table 2

r values of cross-hemagglutinin inhibition assay in study of evolution and antigenic drift of influenza A(H7N9) viruses, China, 2019*

Strain
 Antiserum, r value
H7N9-Re-2
 H7N9-rGD76
 181115
 H7SD12
 H71903
 LN19010
 19225
 19294
H7N9-Re-2 1 0.5 0.25 0.18 0.18 0.25 0.25 0.35
H7N9-rGD76 0.5 1 0.18 0.35 0.35 0.35 0.35 0.25
181115 0.25 0.18 1 0.25 0.25 0.13 0.13 0.13
H7SD12 0.18 0.35 0.25 1 1 1.41 1.41 1
H71903 0.18 0.35 0.25 1 1 1 1.41 1
LN19010 0.25 0.35 0.13 1.41 1 1 1.41 1.41
19225 0.25 0.35 0.13 1.41 1.41 1.41 1 1.41
19294 0.35 0.25 0.13 1 1 1.41 1.41 1

*H7N9-Re-2 and H7N9-rGD76 are vaccine strains widely used in China; both antigen and antiserum of H7N9-Re-2 were purchased from the Harbin Weike Biotechnology Development Company (http://www.hvriwk.com). The antigen of H7N9-Re-2 was available from reassortant avian influenza virus trivalent vaccine. The antigen and antiserum of H7N9-rGD76 were available from Guangzhou South China Biologic Medicine (http://www.gzscbm.com). H71903 is candidate vaccine strain containing the hemagglutinin and neuraminidase genes from H7SD12 and 6 internal genes from A/duck/Guangdong/D7/2007(H5N2). 181115, H7SD12, LN19010, 19225, and 19294 are highly pathogenic H7N9 strains in this study. r values indicate antigenic relatedness. r>1 indicates no significant antigenic difference between the strains; r = 1 indicates the same antigenicity; r<0.5 indicates a statistically significant antigenic difference between the strains. 181115, A/chicken/northeast China/181115/2018(H7N9); H7SD12, A/chicken/east China/H7SD12/2019(H7N9); LN19010, A/chicken/northeast China/LN19010/2019(H7N9); 19225, A/chicken/northeast China/19225/2019(H7N9); 19294, A/chicken/northeast China/19294/2019(H7N9).

Main Article

1These authors contributed equally to this article.

Page created: June 12, 2020
Page updated: July 19, 2020
Page reviewed: July 19, 2020
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