Fatal Measles Inclusion-Body Encephalitis in Adult with Untreated AIDS, France
Christophe Rodriguez, Meriadeg Ar Gouilh, Nicolas Weiss, Sébastian Stroer, Karima Mokhtari, Danielle Seilhean, Bertrand Mathon, Vanessa Demontant, Melissa N’Debi, Guillaume Gricourt, Paul-Louis Woerther, Jean-Michel Pawlotsky, Karl Stefic, Julien Marlet, Pierre-François Dequin, Antoine Guillon, Valérie Pourcher, David Boutolleau, Astrid Vabret, and Sonia Burrel
Author affiliations: Henri Mondor Hospital, Assistance Publique des Hôpitaux de Paris, University of Paris-Est, Créteil, France (C. Rodriguez, V. Demontant, M. N’Debi, G. Gricourt, P.-L. Woerther, J.-M. Pawlotsky); National Reference Laboratory for Measles, Mumps, and Rubella, University Hospital of Caen, Normandie Université, Caen, France (M. Ar Gouilh, A. Vabret); Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Sorbonne-Université, Paris, France (N. Weiss, S. Stroer, K. Mokhtari, D. Seilhean, B. Mathon, V. Pourcher, D. Boutolleau, S. Burrel); National Reference Center for Herpesviruses, Paris (D. Boutolleau, S. Burrel); University Hospital of Tours, University of Tours, Tours, France (K. Stefic, J. Marlet, P.-F. Dequin, A. Guillon); National Reference Center for HIV, Tours (K. Stefic, J. Marlet)
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Figure 2
Figure 2. Histology and immunohistochemical staining of the cerebral cortex in a 28-year-old woman from Romania with untreated AIDS and measles inclusion-body encephalitis. A) Histology shows moderate increased cellular density and absence of nuclear inclusion bodies. Hematoxylin and eosin stain; original magnification ×100. B) Immunohistochemical staining microglial activation with high CD163 immunoreactivity Anti-human CD163 monoclonal antibody; original magnification ×100 and (inset) ×400.
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