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Volume 27, Number 1—January 2021
Research

Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

Tony Wawina-Bokalanga, Bert Vanmechelen, Valentine Lhermitte, Joan Martí-Carreras, Valentijn Vergote, Fara Raymond Koundouno, Joseph Akoi-Boré, Ruth Thom, Tom Tipton, Kimberley Steeds, Kéita Balla Moussa, Ablam Amento, Lies Laenen, Sophie Duraffour, Martin Gabriel, Paula Ruibal, Yper Hall, Mandy Kader-Kondé, Stephan Günther, Guy Baele, Cesar Muñoz-Fontela, Johan Van Weyenbergh, Miles W. Carroll, and Piet MaesComments to Author 
Author affiliations: KU Leuven, Leuven, Belgium (T. Wawina-Bokalanga, B. Vanmechelen, V. Lhermitte, J. Martí-Carreras, V. Vergote, L. Laenen, G. Baele, J. Van Weyenbergh, P. Maes); University Julius Nyerere of Kankan, Conakry, Guinea (F.R. Koudouno); Institut National de Santé Publique, Conakry (J. Akoi-Boré); Public Health England, Salisbury, UK (R. Thom, T. Tipton, K. Steeds, Y. Hall, M.W. Carroll); Centre d'Excellence de Formation et Recherche sur les Maladies Prioritaires en Guinée, Conakry (K.B. Moussa, A. Amento, M. Kader-Kondé); German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Germany (S. Duraffour, M. Gabriel); Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (S. Duraffour, M. Gabriel, P. Ruibal, S. Günther, C. Muñoz-Fontela)

Main Article

Figure 3

Statistical comparison of all inhibitory and activating killer cell immunoglobulin receptors (KIRs) between controls, survivors, and persons who died of Ebola virus disease in Guinea, 2015–2017. A) All inhibitory KIRs with their specific HLA ligands are compared between studied groups. Persons who did and did not survive differed significantly. B) Comparison of activating KIRs with their specific HLA ligands between studied groups. HLA, human leukocyte antigen.

Figure 3. Statistical comparison of all inhibitory and activating killer cell immunoglobulin receptors (KIRs) between controls, survivors, and persons who died of Ebola virus disease in Guinea, 2015–2017. A) All inhibitory KIRs with their specific HLA ligands are compared between studied groups. Persons who did and did not survive differed significantly. B) Comparison of activating KIRs with their specific HLA ligands between studied groups. HLA, human leukocyte antigen.

Main Article

Page created: October 16, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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