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Volume 27, Number 1—January 2021
Dispatch

Detection of Norovirus Variant GII.4 Hong Kong in Asia and Europe, 2017−2019

Martin Chi-Wai Chan1, Sunando Roy, Joseph Bonifacio, Lin-Yao Zhang, Preeti Chhabra, Jenny C.M. Chan, Cristina Celma, Mary Ann Igoy, Sin-Leung Lau, Kirran N. Mohammad, Jan Vinjé, Harry Vennema, Judith Breuer, Marion Koopmans, Miranda de GraafComments to Author , and for NOROPATROL2
Author affiliations: The Chinese University of Hong Kong, Hong Kong, China (M.C.-W. Chan, L.-Y. Zhang, J.C.M. Chan, S.-L. Lau, K.N. Mohammad); University College London, London, UK (S. Roy, J. Breuer); Research Institute for Tropical Medicine, Muntinlupa City, the Philippines (J. Bonifacio, M.A. Igoy); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P. Chhabra, J. Vinjé); Public Health England, London (C. Celma); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (H. Vennema); Erasmus Medical Center, Rotterdam, the Netherlands (M. Koopmans, M. de Graaf)

Main Article

Figure 2

Root-to-tip distance plots of the major capsid protein nucleotide (A) and amino acid (B) sequences of norovirus GII.4 variants. Distance from best-fitting root was calculated using the corresponding maximum-likelihood phylogenetic tree shown in Figure 1. Each circle represents 1 strain color-coded by GII.4 variant; darker shades of color indicate >2 strains of the same variant. R2 values indicate the linearity of the accumulation of virus mutations over time; for nucleotide sequences, R2 = 0.9691, and for amino acid sequences, R2 = 0.9362. An identical set of sequences were used in phylogenetic inference and root-to-tip distance estimation.

Figure 2. Root-to-tip distance plots of the major capsid protein nucleotide (A) and amino acid (B) sequences of norovirus GII.4 variants. Distance from best-fitting root was calculated using the corresponding maximum-likelihood phylogenetic tree shown in Figure 1. Each circle represents 1 strain color-coded by GII.4 variant; darker shades of color indicate >2 strains of the same variant. R2 values indicate the linearity of the accumulation of virus mutations over time; for nucleotide sequences, R2 = 0.9691, and for amino acid sequences, R2 = 0.9362. An identical set of sequences were used in phylogenetic inference and root-to-tip distance estimation.

Main Article

1Current affiliation: Research Office, Food and Health Bureau, Hong Kong, China.

2Members who contributed data are listed at the end of this article.

Page created: November 19, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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