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Volume 27, Number 10—October 2021
CME ACTIVITY - Dispatch

Relapsing Fever Infection Manifesting as Aseptic Meningitis, Texas, USA

Lisa Ellis, Michael W. Curtis, Sarah M. Gunter, and Job E. LopezComments to Author 
Author affiliations: Austin Infectious Disease Consultants, Austin, Texas, USA (L. Ellis); Baylor College of Medicine, Houston, Texas (M.W. Curtis, S.M. Gunter, J.E. Lopez)

Main Article

Figure 2

Immunoblots assessing antibody responses to Borrelia protein lysates and rBipA in samples from a patient in Texas, USA, and a control sample. A, B) Serum (A, upper panel) and cerebrospinal fluid (B, upper panel) samples were used to detect reactivity to Borrelia protein lysates and to rBipA from each species of tickborne relapsing fever spirochete. C) Negative human serum sample (upper panel) and immunoblots (bottom panel) that were reprobed with a monoclonal antibody for the histidine residues fused on the N terminus of each recombinant protein. Asterisks (*) indicates rBipA, which is ≈65 kDa. Molecular masses in kDa are indicated on the left of each immunoblot. Bb, Borreliela (Borrelia) burgdorferi; Bh, B. hermsii; BipA, Borrelia immunogenic protein A; Bp, B. parkeri; Bt, B. turicatae; rBipA, recombinant BipA.

Figure 2. Immunoblots assessing antibody responses to Borrelia protein lysates and rBipA in samples from a patient in Texas, USA, and a control sample. A, B) Serum (A, upper panel) and cerebrospinal fluid (B, upper panel) samples were used to detect reactivity to Borrelia protein lysates and to rBipA from each species of tickborne relapsing fever spirochete. C) Negative human serum sample (upper panel) and immunoblots (bottom panel) that were reprobed with a monoclonal antibody for the histidine residues fused on the N terminus of each recombinant protein. Asterisks (*) indicates rBipA, which is ≈65 kDa. Molecular masses in kDa are indicated on the left of each immunoblot. Bb, Borreliela (Borrelia) burgdorferi; Bh, B. hermsii; BipA, Borrelia immunogenic protein A; Bp, B. parkeri; Bt, B. turicatae; rBipA, recombinant BipA.

Main Article

Page created: August 18, 2021
Page updated: September 20, 2021
Page reviewed: September 20, 2021
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