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Volume 27, Number 10—October 2021

Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade Viruses

Christine H.T. Bui1, Denise I.T. Kuok1, Hin Wo Yeung, Ka-Chun Ng, Daniel K.W. Chu, Richard J. Webby, John M. Nicholls, J.S. Malik Peiris, Kenrie P.Y. Hui, and Michael C.W. ChanComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (C.H.T. Bui, D.I.T. Kuok, H.W. Yeung, K.-C. Ng, D.K.W. Chu, J.M. Nicholls, J.S.M. Peiris, K.P.Y. Hui, M.C.W. Chan); St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (R.J. Webby)

Main Article


Effects of desialylation on influenza A virus hemagglutination of turkey red blood cells*

Virus 0.5% Turkey red blood cells
Untreated Sialidase S† Sialidase C†
Influenza A(H1N1)pdm09 64 64 8
HPAI H5N1/483 256 0 0
HPAI H5N1/SZ1 64 4 4
HPAI H5N6/39715 128 0 0
avHPAI H5N6/DK01 128 128 32
avHPAI H5N6/18259 64 4 4
avHPAI H5N6/MP692 64 64 32
avHPAI H5N8/636099 128 128 8
avHPAI H5N8/642613 256 256 64
avLPAI H5N8/MP5883 32 4 4

*Hemagglutination titers were calculated as the reciprocal of the highest dilution that gave hemagglutination. Experiments were performed in triplicate and led to identical results. Av, avian; HPAI, highly pathogenic avian influenza. †Agilent (

Main Article

1These first authors contributed equally to this article.

Page created: July 30, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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