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Volume 27, Number 11—November 2021
Research

Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Bacteremia and Monocyte Evasion, Rio de Janeiro, Brazil

Alice Slotfeldt Viana1, Ana Maria Nunes Botelho12, Ahmed M. Moustafa1, Craig L.K. Boge, Adriana Lucia Pires Ferreira, Maria Cícera da Silva Carvalho, Márcia Aparecida Guimarães, Bruno de Souza Scramignon Costa3, Marcos Corrêa de Mattos, Sabrina Pires Maciel, Juliana Echevarria-Lima, Apurva Narechania, Kelsey O’Brien, Chanelle Ryan, Jeffrey S. Gerber, Bernadete Teixeira Ferreira Carvalho, Agnes Marie Sá Figueiredo4, and Paul J. Planet4Comments to Author 
Author affiliations: Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (A.S. Viana, A.M.N. Botelho, A.L.P. Ferreira, M.C.S. Carvalho, M.A. Guimarães, B.S.S. Costa, M.C. Mattos, S.P. Maciel, J. Echevarria-Lima, B.T.F. Carvalho, A.M.S. Figueiredo); Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA (A.M. Moustafa, C.L.K. Boge, K. O’Brien, C. Ryan, J.S. Gerber, P.J. Planet); Diagnósticos da América S.A., Duque de Caxias, Brazil (A.L.P. Ferreira); American Museum of Natural History, New York, New York, USA (A. Narechania, P.J. Planet); University of Pennsylvania, Philadelphia (J.S. Gerber, P.J. Planet)

Main Article

Figure 5

Histograms showing count versus green fluorescence intensity of THP-1 cells exposed or not to MRSA isolates, Rio de Janeiro, Brazil, 2014–2017. A) Acquisition of THP-1 cells not exposed to MRSA. B) Acquisition of THP-1 cells exposed to representative strains of 3 MRSA lineages. Blue indicates ST5-SCCmecIV-t002, strain CR14-026 (CC5-Basal lineage); green indicates ST5-SCCmecII-t539, strain CR15-071 (CC5-IIA lineage); and red indicates ST105-SCCmecII-t002, strain CD16–016 (CC5-IIB lineage). C) Acquisition of THP-1 cells exposed to representative strains of 3 MRSA lineages. Blue indicates ST5-SCCmecIV-t002, strain CHU15–056 (CC5-Basal lineage); green indicates ST5-SCCmecII-t539, strain CR14–016 (CC5-IIA lineage); and red indicates ST105-SCCmecII-t002 strain CD15–276 (CC5-IIB lineage). CC, clonal complex; FL1-H, forward light 1 height; MRSA, methicillin-resistant Staphylococcus aureus; SCC, staphylococcal cassette chromosome; ST, sequence type.

Figure 5. Histograms showing count versus green fluorescence intensity of THP-1 cells exposed or not to MRSA isolates, Rio de Janeiro, Brazil, 2014–2017. A) Acquisition of THP-1 cells not exposed to MRSA. B) Acquisition of THP-1 cells exposed to representative strains of 3 MRSA lineages. Blue indicates ST5-SCCmecIV-t002, strain CR14-026 (CC5-Basal lineage); green indicates ST5-SCCmecII-t539, strain CR15-071 (CC5-IIA lineage); and red indicates ST105-SCCmecII-t002, strain CD16–016 (CC5-IIB lineage). C) Acquisition of THP-1 cells exposed to representative strains of 3 MRSA lineages. Blue indicates ST5-SCCmecIV-t002, strain CHU15–056 (CC5-Basal lineage); green indicates ST5-SCCmecII-t539, strain CR14–016 (CC5-IIA lineage); and red indicates ST105-SCCmecII-t002 strain CD15–276 (CC5-IIB lineage). CC, clonal complex; FL1-H, forward light 1 height; MRSA, methicillin-resistant Staphylococcus aureus; SCC, staphylococcal cassette chromosome; ST, sequence type.

Main Article

1These first authors contributed equally to this article.

2Current affiliation: Fluminense Federal University, Niteroi, Brazil.

3Current affiliation: Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

4These authors were co–principal investigators.

Page created: August 16, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
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