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Volume 27, Number 2—February 2021
CME ACTIVITY - Synopsis

Plasmodium ovale wallikeri and P. ovale curtisi Infections and Diagnostic Approaches to Imported Malaria, France, 2013–2018

Valentin JosteComments to Author , Justine Bailly, Véronique Hubert, Cécile Pauc, Mathieu Gendrot, Emilie Guillochon, Marylin Madamet, Marc Thellier, Eric Kendjo, Nicolas Argy, Bruno Pradines, Sandrine Houzé, and on behalf of the French National Reference Center for Imported Malaria Study Group1
Author affiliations: Centre National de Référence du Paludisme, Paris, France (V. Joste, J. Bailly, V. Hubert, C. Pauc, N. Argy, S. Houzé); Université de Paris, Paris (N. Argy, S. Houzé); Laboratoire de Parasitologie-Mycologie, Paris (V. Joste, N. Argy, S. Houzé); Institut de Recherche Biomédicale des Armées, Marseille, France (M. Gendrot, M. Madamet, B. Pradines); Aix–Marseille Université, Marseille (M. Gendrot, M. Madamet, B. Pradines); Instituts Hospitalo–Universitaires Méditerranée Infection, Marseille (M. Gendrot, M. Madamet, B. Pradines); Centre National de Référence du Paludisme, Marseille (M. Madamet, B. Pradines); Sorbonne Université, Paris, France (M. Thellier, E. Kendjo)

Main Article

Table 2

Comparison of aldolase and pLDH-RDT efficiency in Plasmodium ovale wallikeri and P. ovale curtisi infection diagnosis, France, January 2013–December 2018*

RDT result Parasite density, parasites/μL LDH
 Aldolase
P. ovale P. ovale wallikeri P. ovale curtisi P. ovale P. ovale wallikeri P. ovale curtisi
Positive 55 (10.6) 45 (16) 10 (4.2) 211 (47.8) 120 (50) 91 (45.3)
<1,000 5 (3.9) 3 (3.9) 2 (3.9) 25 (19.5) 16 (20) 9 (17.6)
1,000–5,000 15 (9.4) 14 (15) 1 (1.5) 65 (40.6) 42 (54.5) 23 (33.8)
5,000–10,000 6 (7.8) 5 (12) 1 (2.8) 44 (57.1) 24 (66.7) 20 (57.1)
10,000–50,000 16 (16.2) 11 (20) 5 (11.4) 67 (67.7) 29 (78.4) 38 (86.4)
>50,000
 13 (86.7)
 12 (86)
 1 (100)
10 (100)
 9 (100)
 1 (100)
Negative
465 (89.4)
 237 (84)
 228 (95.8)
230 (52.2)
 120 (50)
 110 (54.7)
p value <0.001
 0.322

*Values are no. (%) patients except as indicated. LDH, lactate dehydrogenase; pLDH, plasmodium lactate dehydrogenase; RDT, rapid diagnostic test.
†Proportions of positive and negative LDH or aldolase-RDT were compared for P. ovale wallikeri and P. ovale curtisi by using a χ2 test.

Main Article

1Additional members of the French National Reference Center for Imported Malaria Study Group who contributed data are listed at the end of this article.

Page created: January 04, 2021
Page updated: January 21, 2021
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