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Volume 27, Number 2—February 2021
Research Letter

Intrauterine Transmission of SARS-CoV-2

Emanuele T. S. Stonoga1, Laura de Almeida Lanzoni1, Patricia Zadorosnei Rebutini1Comments to Author , André Luiz Permegiani de Oliveira, Jullie Anne Chiste, Cyllian Arias Fugaça, Daniele M. M. Prá, Ana Paula Percicote, Andrea Rossoni, Meri Bordignon Nogueira, Lucia de Noronha, and Sonia Mara Raboni
Author affiliations: Hospital de Clínicas da Universidade Federal do Paraná, Parana, Brazil (E.T.S. Stonoga, L.A. Lanzoni, J.A. Chiste, C.A. Fugaça, M.B. Nogueira); Pontifícia Universidade Católica do Paraná, Parana (P.Z. Rebutini, A.L.P. Oliveira, D.M. Marani Prá, L. de Noronha); Universidade Federal do Paraná, Parana (A.P. Percicote, A. Rossoni, S.M. Raboni)

Main Article

Table

Results of PCR for severe acute respiratory syndrome coronavirus 2 in a pregnant woman and fetus, Brazil, 2020*

Sample Day Cycle threshold†
ORF1ab N RNaseP‡
Maternal nasopharyngeal swab sample 0 21.0 24.0 23.0
Maternal nasopharyngeal swab sample 4 20.9 24.8 29.9
Umbilical cord blood 8 31.9 30.3 27.0
Placenta§ 8 24.5 25.5 25.6
Fetal liver 9 Undetectable Undetectable 29.0
Fetal spleen 9 Undetectable Undetectable 27.8
Fetal lungs 9 Undetectable Undetectable 25.7
Fetal central nervous system 9 Undetectable Undetectable 29.4
Fetal skeletal muscle 9 Undetectable Undetectable 26.5
Fetal heart 9 Undetectable Undetectable 26.5
Fetal ovary 9 Undetectable Undetectable 25.4

*PCR conducted using XGEN MASTER COVID-19 Kit (Mobius Life Science, Inc, https://mobiuslife.com.br). N, nucleocapsid protein gene; ORF, open reading frame.
†Cycle threshold value is considered positive if both viral genes are <38.
‡PCR is selective for human RNaseP gene as a control for sample integrity.
§Insufficient sample.

Main Article

1These first authors contributed equally to this article.

Page created: November 09, 2020
Page updated: January 24, 2021
Page reviewed: January 24, 2021
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