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Volume 27, Number 3—March 2021
Research

Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States

Pranay R. RandadComments to Author , Jesper Larsen, Hülya Kaya, Nora Pisanic, Carly Ordak, Lance B. Price, Maliha Aziz, Maya L. Nadimpalli, Sarah Rhodes, Jill R. Stewart, Dave C. Love, David Mohr, Meghan F. Davis, Lloyd S. Miller, Devon Hall, Karen C. Carroll, Trish M. Perl, and Christopher D. Heaney
Author affiliations: Johns Hopkins University, Baltimore, Maryland, USA (P.R. Randad, N. Pisanic, C. Ordak, D.C. Love, D. Mohr, M.F. Davis, L.S. Miller, K.C. Carroll, T.M. Perl, C.D. Heaney); Statens Serum Institut, Copenhagen, Denmark (J. Larsen, H. Kaya); George Washington University, Washington, DC, USA (L.B. Price, M. Aziz); Tufts University, Boston, Massachusetts, USA (M.L. Nadimpalli); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (S. Rhodes, J.R. Stewart); Rural Empowerment Association for Community Help (REACH), Warsaw, North Carolina, USA (D. Hall); University of Texas Southwestern Medical Center, Dallas, Texas, USA (T.M. Perl)

Main Article

Figure 1

Maximum-likelihood tree demonstrating population structure of Staphylococcus aureus clonal complex (CC) 9 isolates from humans and livestock in North Carolina, USA, and reference sequences. A total of 81 S. aureus CC9 isolates from human and livestock specimens were included in this midpoint-rooted maximum-likelihood phylogeny based on 3,847 core genome single-nucleotide polymorphisms. S. aureus isolates belonged to 3 phylogeographically distinct clades (C1–C3). All the North Carolina collection isolates were included in C3. IEC genes are shown in columns 1, scn; 2, sak; and 3, chp. MRSA is shown in column 4. AMR genes are shown in columns 5, mecA; 6, tet(K); 7, tet(L); 8, tet(T); 9, erm(A); 10, erm(B); 11, erm(C); 12, vga(A)LC; 13, lnu(A); 14, lnu(B); 15, str; 16, spc; 17, aadD; 18, aac(6); 19, ant(6)-1a; 20, dfrG; and 21, dfrK. Scale bar indicates nucleotide substitutions per site. AMR, antimicrobial resistance; Chick, chicken; COO, country of origin; IEC, immune evasion cluster; MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus; NA, not applicable.

Figure 1. Maximum-likelihood tree demonstrating population structure of Staphylococcus aureus clonal complex (CC) 9 isolates from humans and livestock in North Carolina, USA, and reference sequences. A total of 81 S. aureus CC9 isolates from human and livestock specimens were included in this midpoint-rooted maximum-likelihood phylogeny based on 3,847 core genome single-nucleotide polymorphisms. S. aureus isolates belonged to 3 phylogeographically distinct clades (C1–C3). All the North Carolina collection isolates were included in C3. IEC genes are shown in columns 1, scn; 2, sak; and 3, chp. MRSA is shown in column 4. AMR genes are shown in columns 5, mecA; 6, tet(K); 7, tet(L); 8, tet(T); 9, erm(A); 10, erm(B); 11, erm(C); 12, vga(A)LC; 13, lnu(A); 14, lnu(B); 15, str; 16, spc; 17, aadD; 18, aac(6); 19, ant(6)-1a; 20, dfrG; and 21, dfrK. Scale bar indicates nucleotide substitutions per site. AMR, antimicrobial resistance; Chick, chicken; COO, country of origin; IEC, immune evasion cluster; MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus; NA, not applicable.

Main Article

Page created: January 20, 2021
Page updated: February 21, 2021
Page reviewed: February 21, 2021
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