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Volume 27, Number 3—March 2021
Dispatch

Bedaquiline as Treatment for Disseminated Nontuberculous Mycobacteria Infection in 2 Patients Co-Infected with HIV

Eliza GilComments to Author , Nicola Sweeney, Veronica Barrett, Stephen Morris-Jones, Robert F. Miller, Victoria J. Johnston, and Michael Brown
Author affiliations: University College London Hospitals, National Health Service Foundation Trust, London, UK (E. Gil, N. Sweeney, V. Barrett, S. Morris-Jones, V.J. Johnston, M. Brown); Central and North West London National Health Service Foundation Trust, London (R.F. Miller); University College London, London (R.F. Miller); London School of Hygiene and Tropical Medicine, London (R.F. Miller, V.J. Johnston, M. Brown)

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Table 1

MICs and CLSI interpretation as reported by Public Health England reference laboratory for all drugs tested against Mycobacterium abscessus isolate from case-patient 1 (5)*

Drug MIC, mg/L CLSI interpretation
Amikacin
 Month 0: 16 Sensitive
Month 3: 32
 Intermediate
Cefoxitin 128 Resistant
Ciprofloxacin >4 Resistant
Clarithromycin >16 Resistant (phenotype suggestive of inducible resistance)
Cotrimoxazole >8/152 Resistant
Doxycycline >16 Resistant
Imipenem
 16
 Intermediate
Linezolid
 Month 0: 32 Resistant
Month 3: 16
 Intermediate
Moxifloxacin >8 Resistant
Tigecycline 2 No defined breakpoints
Tobramycin 8 Resistant

*MICs were obtained for the initial isolate of the patient at month 0, and again at month 3. Where duplicated, values were consistent, except for amikacin and linezolid, where both MICs are included. CLSI, Clinical and Laboratory Standards Institute.

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Page created: November 11, 2020
Page updated: February 21, 2021
Page reviewed: February 21, 2021
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