Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 3—March 2021
CME ACTIVITY - Research

Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008–2018

Eun Jeong Won1, Min Ji Choi1, Mi-Na Kim, Dongeun Yong, Wee Gyo Lee, Young Uh, Taek Soo Kim, Seung Ah Byeon, Seung Yeob Lee, Soo Hyun Kim, and Jong Hee ShinComments to Author 
Author affiliations: Chonnam National University Medical School, Gwangju, South Korea (E.J. Won, M.J. Choi, S.A. Byeon, S.Y. Lee, S.H. Kim, J.H. Shin); Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (M.-N. Kim); Yonsei University College of Medicine, Seoul (D. Yong); Ajou University School of Medicine, Suwon, South Korea (W.G. Lee); Yonsei University Wonju College of Medicine, Wonju, South Korea (Y. Uh); Seoul National University College of Medicine, Seoul (T.S. Kim)

Main Article

Figure

Kaplan–Meier and log-rank (Mantel–Cox) pairwise analyses of survival of patients with Candida glabrata candidemia, based on patient data and cultures collected during a multicenter surveillance study, South Korea, 2008–2018. A) Cumulative survival curves of 64 patients infected with fluconazole-resistant (FR) bloodstream infection (BSI) isolates. The cumulative mortality rates of 64 patients infected with FR C. glabrata BSIs increased over time (day 7 [29.7%], day 30 [60.9%], day 60 [68.8%], and day 90 [78.1%]). B) Cumulative survival curves of patients infected with fluconazole-susceptible dose-dependent (F-SDD) BSI isolates (297 patients total) in 2009 (75 patients in 6 hospitals), 2014 (97 patients in 7 hospitals), 2017 (75 patients in 9 hospitals), and 2018 (50 patients in 8 hospitals). The 30-day mortality rate of the F-SDD group was 34.7% in 2010, 39.2% in 2014, 37.3% in 2017, and 32.0% in 2018. The cumulative mortality rates of 297 patients infected with F-SDD BSI isolates of C. glabrata were found to be 18.5% at day 7 (p = 0.084), 36.4% at day 30 (p = 0.001), 41.8% at day 60 (p<0.001), and 43.8% at day 90 (p<0.001).

Figure. Kaplan–Meier and log-rank (Mantel–Cox) pairwise analyses of survival of patients with Candida glabrata candidemia, based on patient data and cultures collected during a multicenter surveillance study, South Korea, 2008–2018. A) Cumulative survival curves of 64 patients infected with fluconazole-resistant (FR) bloodstream infection (BSI) isolates. The cumulative mortality rates of 64 patients infected with FR C. glabrata BSIs increased over time (day 7 [29.7%], day 30 [60.9%], day 60 [68.8%], and day 90 [78.1%]). B) Cumulative survival curves of patients infected with fluconazole-susceptible dose-dependent (F-SDD) BSI isolates (297 patients total) in 2009 (75 patients in 6 hospitals), 2014 (97 patients in 7 hospitals), 2017 (75 patients in 9 hospitals), and 2018 (50 patients in 8 hospitals). The 30-day mortality rate of the F-SDD group was 34.7% in 2010, 39.2% in 2014, 37.3% in 2017, and 32.0% in 2018. The cumulative mortality rates of 297 patients infected with F-SDD BSI isolates of C. glabrata were found to be 18.5% at day 7 (p = 0.084), 36.4% at day 30 (p = 0.001), 41.8% at day 60 (p<0.001), and 43.8% at day 90 (p<0.001).

Main Article

1These first authors contributed equally to this article.

Page created: January 04, 2021
Page updated: March 01, 2021
Page reviewed: March 01, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external