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Volume 27, Number 3—March 2021
CME ACTIVITY - Research

Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008–2018

Eun Jeong Won1, Min Ji Choi1, Mi-Na Kim, Dongeun Yong, Wee Gyo Lee, Young Uh, Taek Soo Kim, Seung Ah Byeon, Seung Yeob Lee, Soo Hyun Kim, and Jong Hee ShinComments to Author 
Author affiliations: Chonnam National University Medical School, Gwangju, South Korea (E.J. Won, M.J. Choi, S.A. Byeon, S.Y. Lee, S.H. Kim, J.H. Shin); Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (M.-N. Kim); Yonsei University College of Medicine, Seoul (D. Yong); Ajou University School of Medicine, Suwon, South Korea (W.G. Lee); Yonsei University Wonju College of Medicine, Wonju, South Korea (Y. Uh); Seoul National University College of Medicine, Seoul (T.S. Kim)

Main Article

Table 3

Pdr1 AAS in 59 FR isolates of Candida glabrata BSI isolates and their MLST genotypes, based on cultures collected during a multicenter surveillance study, South Korea, 2008–2018*

MLST genotype No. isolates Pdr1 AAS (no. isolates)†
Inhibition domain Fungal-specific transcription factor domain Activation domain Other regions
ST7 34 P327L (2), G334V (1), E340G (1), E340K (1), G346S (1), L347F (1), L375P (1), R376Q (1), S391L (1) H576Y (2), G583C (1) P927S (1), G943S (1), S947L (1), D954N (1), G1088E (1), Y1106N (1) S236N (1), P258S (1), P258L (1), V260A (1),L280S (1), Y556C (1), E714D (1), T752I (1), N768D (1), R772K (1), K776E (1), G788W (2), L825P (1), T885A (1)
ST26 6 K365E (1), R376Q (1), F377I (1), E388Q (1) N1091D (1) S316I (1)
ST3 6 L347F (1) Y584D (1) T1080N (1), Y1106N (1) A731E (1), N764D (1)
ST1 2 T607A (2)
ST2 2 G346S (2)
ST10 2 S337F (1), I392M (1)
ST55 2 F294S (1), P258S (1)
ST6 1 G1079R (1)
ST22 1 Y932C (1)
ST59 1 E369K (1)
Others
 2
L935F (1)
P696L (1)
No. (%) isolates 59 20 (33.9) 7 (11.9) 11 (18.6) 21 (35.6)
No. (%) Pdr1 AAS 49 15 (30.6) 5 (10.2) 10 (20.4) 19 (38.8)

*AAS, amino acid substitutions; BSI, bloodstream infection; FR, fluconazole-resistant; MLST, multilocus sequence typing; ST, sequence type.
†Previously reported Pdr1 AAS are shown in bold.

Main Article

1These first authors contributed equally to this article.

Page created: January 04, 2021
Page updated: March 01, 2021
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