Volume 27, Number 4—April 2021
Dispatch
Improving Treatment and Outcomes for Melioidosis in Children, Northern Cambodia, 2009–2018
Table 1
Characteristics for 355 children who had culture-confirmed melioidosis, northern Cambodia, 2009–2018*
| Characteristic | Value |
|---|---|
| Median age, y (IQR) |
5.7 (3.1–9.5) |
| Sex | |
| M | 255 (57.5) |
| F |
100 (42.5) |
| Concurrent condition, n = 355 | 14 (3.9) |
| Thalassemia | 4 |
| Systemic lupus erythematosus | 2 |
| Suspected underlying immunodeficiency | 2 |
| Asthma | 1 |
| Epilepsy | 1 |
| Acute lymphoblastic leukemia | 1 |
| Congenital heart disease | 1 |
| Chronic kidney disease | 1 |
| Pure red cell aplasia |
1 |
| Clinical manifestations, n = 355 | |
| Parotitis | 97 (27.3) |
| Skin or soft tissue infection | 96 (27.0) |
| Pneumonia | 69 (19.4) |
| Lymphadenitis | 58 (16.3) |
| Meningitis | 1 (0.3) |
| Multifocal infection | 12 (3.4) |
| Other† | 8 (2.3) |
| Unknown‡ |
15 (4.5) |
| Management strategy, n = 355 | |
| Admitted case-patients | 212 (59.7) |
| Case-patients admitted at first presentation | 145 (40.8) |
| Empiric treatment with effective intensive-phase therapy | 51 |
| Treatment with effective intensive-phase therapy within 48 h | 38 |
| Treatment with effective intensive-phase therapy after 48 h | 40 |
| No effective intensive-phase therapy received§ | 11 |
| Treatment information not available |
5 |
| Admitted to intensive care unit, n = 212 | 52 (24.5) |
| Surviving patients completing 12 weeks of eradication therapy, n = 306 | 102 (33.3) |
| No. patients treated successfully with only oral antimicrobial drugs | 39 |
*Values are no. (%) except as indicated. IQR, interquartile range. †Clinical manifestations for patients classified as Other included mandibular osteomyelitis (2), diarrheal disease (2), vaginitis (2), mastoiditis (1), and septic arthritis (1). ‡Clinical manifestations were unknown for 15 patients: 10 were bacteremic and 5 had Burkholderia pseudomallei isolated from pus swabs. §A total of 9 children died within 24 h (before culture results were available), and 2 were switched directly to oral treatment.
1These authors contributed equally to this article.
Page created: December 06, 2020
Page updated: March 18, 2021
Page reviewed: March 18, 2021
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