Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 4—April 2021
Dispatch

Improving Treatment and Outcomes for Melioidosis in Children, Northern Cambodia, 2009–2018

Arjun Chandna1Comments to Author , Moritz Bonhoeffer1, Thyl Miliya, Keang Suy, Sena Sao, and Paul Turner
Author affiliations: Angkor Hospital for Children, Siem Reap, Cambodia (A. Chandna, M. Bonhoeffer, T. Miliya, K. Suy, S. Sao, P. Turner); University of Oxford, Oxford, UK (A. Chandna, P. Turner)

Main Article

Table 2

Risk factors for death of children who had culture-confirmed Burkholderia pseudomallei infection, northern Cambodia, 2009–2018*

Characteristic Survivors Nonsurvivors Unadjusted OR (95% CI); p value Adjusted OR (95% CI); p value
Whole population, n = 355 n = 312 n = 43
Female sex 126/312 (40.4) 25/43 (58.1) 2.05 (1.07–3.91); 0.03 1.58 (0.71–3.53); 0.26
Age <5 y 126/312 (40.4) 25/43 (58.1) 2.05 (1.07–3.91); 0.03 0.69 (0.28–1.60); 0.39
Pneumonia† 34/312, (10.9) 35/43 (81.4) 35.77 (15.34–83.41); <0.001 38.99 (16.46–104.01); <0.001
Bacteremia‡ 31/114 (27.2) 42/43 (97.7) 112.45 (14.83–852.47); <0.001 70.24 (13.73–1,289.14); <0.001
Severe undernutrition§
 32/225 (14.2)
 12/37 (32.4)
 2.90 (1.32–6.34); 0.008
 1.36 (0.51–3.52); 0.53
Children <10 y of age who had blood culture, n = 128 n = 91 n = 37
Female sex 39/91 (42.9) 20/37 (54.1) 1.57 (0.73–3.38); 0.25 1.24 (0.44–3.46); 0.679
Age <5 y 54/91 (59.3) 23/37 (62.2) 1.13 (0.51–2.47); 0.77 0.70 (0.21–2.18); 0.542
Pneumonia† 31/91 (34.1) 30/37 (81.1) 8.29 (3.27–21.02); <0.001 3.97 (1.22–14.43); 0.027
Bacteremia 29/91 (31.9) 36/37 (97.3) 76.97 (10.05–589.16); <0.001 57.09 (10.80–1,063.54); <0.001
Severe undernutrition 17/91 (18.7) 12/37 (32.4) 2.09 (0.88–4.97); 0.09 2.08 (0.62–7.72); 0.247

*Values are no. positive/no. tested (%) except as indicated. OR, odds ratio.
†Pneumonia was defined according to the working diagnosis of the treating clinical team, taking into consideration clinical, laboratory, and radiologic information. A total of 89.9% (62/69) of children who were given a diagnosis of pneumonia had a chest radiograph.
‡Risk for bacteremia assessed in children who had a blood culture collected (n = 157). 
§Risk for severe undernutrition (weight-for-age z score <–3) assessed in children <10 y of age (n = 262; a weight measurement was available for 95.6% [262/274] of children <10 y of age). Multivariate analyses adjusted for sex, age <5 years, and pneumonia. Subgroup analysis (n = 128). Includes only children <10 y of age who had a blood culture collected.

Main Article

1These authors contributed equally to this article.

Page created: December 06, 2020
Page updated: March 18, 2021
Page reviewed: March 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external