Volume 27, Number 5—May 2021
CME ACTIVITY - Research
Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy
Marianna Rossi, Liliane Chatenoud, Floriana Gona, Isabella Sala, Giovanni Nattino, Alessia D'Antonio, Daniele Castelli, Teresa Itri, Paola Morelli, Sara Bigoni, Chiara Aldieri, Roberto Martegani, Paolo A. Grossi, Cecilia Del Curto, Stefania Piconi, Sara G. Rimoldi, Paola Brambilla, Paolo Bonfanti, Evelyn Van Hauwermeiren, Massimo Puoti, Gianni Gattuso, Chiara Cerri, Mario C. Raviglione, Daniela M. Cirillo, Alessandra Bandera, Andrea Gori
, and The KPC-Kp Study Group1
, and The KPC-Kp Study Group1
Table 1
Characteristics of patients identified in multicenter surveillance for Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae, Italy*
| Characteristics | KPC-Kp patients, n = 1,071 |
|---|---|
| Sex | |
| M | 694 (64.8) |
| F |
377 (35.2) |
| Median age (IQR) |
72 (61–80) |
| Ward of isolation | |
| Intensive care unit | 275 (25.7) |
| Infectious diseases | 81 (7.6) |
| Surgery | 149 (13.9) |
| Geriatrics | 47 (4.4) |
| Oncology | 34 (3.2) |
| Hematology | 42 (3.9) |
| Other medical wards |
443 (41.4) |
| KPC-Kp colonization in previous 12 mo | 333 (31.1) |
| Hospitalization in previous 12 mo | 865 (80.8) |
| Antimicrobial therapy in the 30 d before hospitalization | 782 (73.0) |
| Major surgery in the previous 30 d |
262 (24.4) |
| Underlying conditions† | 989 (92.3) |
| Congestive heart failure | 192 (17.9) |
| Peripheral vascular disease | 197 (18.4) |
| Cerebrovascular disease | 205 (19.1) |
| Chronic lung disease | 202 (18.9) |
| Chronic renal failure | 304 (28.4) |
| Cancer | 244 (22.8) |
| Diabetes |
163 (15.2) |
| Charlson index, median (IQR) | 6 (4–8) |
| Central venous catheter at isolation | 414 (38.7) |
| Urinary catheter at isolation | 562 (52.5) |
| Immunosuppressive therapy | 209 (19.5) |
| Days of hospitalization, median (IQR) |
25 (14–45) |
| KPC-Kp acquisition characteristics‡ | |
| Severe infection | 221 (20.6) |
| Mild infection | 109 (10.2) |
| Colonizationsur |
741 (69.2) |
| Median time from hospitalization to isolation of strain, d (IQR)‡ | |
| Severe infection | 12 (2–22) |
| Mild infection | 11 (2–25) |
| Colonizationsur |
6 (1–17) |
| Median time from strain isolation to discharge or death, d (IQR)‡ | |
| Severe infection | 18 (9–35) |
| Mild infection | 20 (12–35) |
| Colonizationsur | 13 (6–22) |
*Values are no. (%) except as indicated. IQR, interquartile range; KPC-Kp, Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae. †Underlying conditions and devices are listed when present in >10% of patients. ‡Severe infection included bloodstream or lower respiratory tract infection plus septic shock from other sites; Mild infection included infections from other sites; and colonizedsur patients were identified through surveillance protocols.
1Group collaborators are listed at the end of this article.
Page created: March 05, 2021
Page updated: April 22, 2021
Page reviewed: April 22, 2021
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