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Volume 27, Number 5—May 2021
Dispatch

Whole-Genome Sequencing of Shiga Toxin–Producing Escherichia coli OX18 from a Fatal Hemolytic Uremic Syndrome Case

Kenichi LeeComments to Author , Atsushi Iguchi, Kazuhiro Uda, Sohshi Matsumura, Isao Miyairi, Kenji Ishikura, Makoto Ohnishi, Junji Seto, Kanako Ishikawa, Noriko Konishi, Hiromi Obata, Ichiro Furukawa, Hiromi Nagaoka, Hirotaka Morinushi, Natsuki Hama, Ryohei Nomoto, Hiroshi Nakajima, Hideaki Kariya, Mitsuhiro Hamasaki, and Sunao Iyoda
Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (K. Lee, M. Ohnishi, S. Iyoda); University of Miyazaki, Miyazaki, Japan (A. Iguchi); National Center for Child Health and Development, Tokyo (K. Uda, S. Matsumura, I. Miyairi, K. Ishikura); Tokyo Metropolitan Children’s Medical Center, Tokyo (K. Uda); Kanagawa Children’s Medical Center, Kanagawa, Japan (S. Matsumura); Kitasato University School of Medicine, Tokyo (K. Ishikura); Yamagata Prefectural Institute of Public Health, Yamagata, Japan (J. Seto); Ibaraki Prefectural Institute of Public Health, Ibaraki, Japan (K. Ishikawa); Tokyo Metropolitan Institute of Public Health, Tokyo (N. Konishi, H. Obata); Kanagawa Prefectural Institute of Public Health, Kanagawa (I. Furukawa); Shizuoka Institute of Environment and Hygiene, Shizuoka, Japan (H. Nagaoka, H. Morinushi); Kobe Institute of Health, Hyogo, Japan (N. Hama, R. Nomoto); Okayama Prefectural Institute for Environmental Science and Public Health, Okayama, Japan (H. Nakajima, H. Kariya); Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan (M. Hamasaki)

Main Article

Table

OX18 isolates used in study of whole-genome sequencing of Shiga toxin–producing Escherichia coli OX18 from a fatal hemolytic uremic syndrome case, Japan*

Strain Year isolated Source Symptoms H genotype Phylogenetic group MLST stx subtype
 Accession no.
stx1 stx2 Draft genome Short reads
JNE101081 2010 Human BD H34 E 9185 1a ND BNCS00000000 SAMD00244533
JNE130471 NA Swine NA H34 E 9185 1a ND BNCT00000000 SAMD00244534
JNE130573 2012 Human D H19 B1 205 ND 2a BNCU00000000 SAMD00244535
JNE133347 2012 Human AC H2 B1 9397 ND 2e BNCV00000000 SAMD00244536
JNE150598 2015 Human BD H19 B1 205 ND 2a BNCW00000000 SAMD00244537
JNE151350 2015 Human AC H19 B1 205 ND 2d BNCX00000000 SAMD00244538
JNE170426 2017 Human HUS, death H2 B1 847 ND 2a BNCY00000000 SAMD00244539
JNE180342 2018 Human AC H8 B1 Novel 1a 2d BNCZ00000000 SAMD00244540
JNE181771 2018 Human HUS H19 B1 205 ND 2a BNDA00000000 SAMD00244541
JNE182474 2018 Human BD H19 B1 205 ND 2a BNDB00000000 SAMD00244542
JNE182523 NA Human NA H19 B1 205 ND 2a BNDC00000000 SAMD00244543
JNE191031 2019 Human BD H19 B1 205 ND 2a BNDD00000000 SAMD00244544
JNE192124 2019 Human AC H19 B1 205 ND 2a BNDE00000000 SAMD00244545
JNE192333 2019 Human AC H28 B1 1056 1d ND BNDF00000000 SAMD00244546
A140161 2010 Cattle NA H19 B1 205 ND 2a BNDG00000000 SAMD00244547
A140164 2010 Cattle NA H19 B1 205 ND 2a BNDH00000000 SAMD00244548
A140165 2010 Cattle NA H19 B1 205 ND 2a BNDI00000000 SAMD00244549
A140286 2012 Cattle NA H19 B1 205 ND 2a BNDJ00000000 SAMD00244550
A140453 2010 Cattle NA H19 B1 Novel 1a 2a BNDK00000000 SAMD00244551
A140462 2010 Cattle NA H19 B1 205 1a ND BNDL00000000 SAMD00244552
A140486 2014 Cattle NA H19 B1 205 ND 2a×2† BNDM00000000 SAMD00244553
A150011 2014 Cattle NA H19 B1 205 ND 2a×2† BNDN00000000 SAMD00244554
A150026 2014 Cattle NA H19 B1 205 ND 2a×2† BNDO00000000 SAMD00244555
A150037 2015 Cattle NA H19 B1 205 ND 2a×2† BNDP00000000 SAMD00244556
A150038 2015 Cattle NA H19 B1 205 ND 2a×2† BNDQ00000000 SAMD00244557
A150039 2015 Cattle NA H19 B1 205 ND 2a×2† BNDR00000000 SAMD00244558

*AC, asymptomatic carrier; BD, bloody diarrhea; D, diarrhea; HUS, hemolytic uremic syndrome; NA, not available; ND, not detected. 
†2a×2, two copies of stx2a were detected.

Main Article

Page created: February 21, 2021
Page updated: April 21, 2021
Page reviewed: April 21, 2021
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