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Volume 27, Number 6—June 2021
Research

Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA

Mariana M. Lanata1, Huanyu Wang, Kathy Everhart, Melisa Moore-Clingenpeel, Octavio Ramilo, and Amy LeberComments to Author 
Author affiliation: Nationwide Children’s Hospital, Columbus, Ohio, USA

Main Article

Table 1

Patient demographics and clinical characteristics of children infected with macrolide-sensitive and macrolide-resistant strains of Mycoplasma pneumoniae, Ohio, USA, 2015–2019*

Characteristic MRMp, n = 12 MSMp, n = 332 p value
Sex 0.9046
M 7 (55) 175 (53)
F
5 (45)
157 (47)

Year 0.6508
2015 4 (33) 146 (44)
2016 1 (8) 51 (15)
2017 2 (17) 52 (16)
2018 5 (42) 73 (22)
2019
0
10 (3)

Age, y, mean (SD)
9.13 (3.74)
8.73 (4.62)
0.7683
Previous visits
Any previous visits 8 (67) 188 (57) 0.4901
No. previous visits, median (IQR)
1.5 (1–2)
1 (1–2)
0.3491
Underlying conditions 6 (50) 139 (42) 0.5752
Chronic immunosuppression 1 (8) 5 (2) 0.1392
Up to date in vaccines
12 (100)
316 (97)
>0.9999
Inpatient 6 (50) 130 (39) 0.551
Median duration of hospitalization, d (IQR)
8 (6–10)
2 (1.5–3)
0.0132
PICU 3 (25) 21 (6) 0.0433
Median duration of PICU stay, d (IQR)
2 (1–8)
2 (1.5–5)
0.8596
Hypoxemia 3 (25) 73 (23) >0.9999
Median duration of O2 support, d (IQR) 4 (1–8.5) 1 (0.5–2) 0.1302
Mechanical ventilation
1 (33)
6 (8)
0.2487
Median duration of symptoms, d (IQR)
7 (6.5–13)
7 (5–10)
0.3324
Fever 11 (92) 271 (81) 0.7024
Median duration of fever, d (IQR) 4 (2–7) 4 (2–7) 0.984
Median maximum temperature, °C (IQR)
38.4 (38.1–39.4)
39.1 (38.4–39.7)
0.0415
Fatigue 5 (42) 91 (27) 0.3298
Decreased appetite/oral food intake 4 (33) 125 (38) >0.9999
Decreased urine output 0 22 (7) >0.9999
Cough 12 (100) 320 (96) >0.9999
Shortness of breath/respiratory distress 5 (42) 91 (27) 0.3268
Sore throat 0 67 (20) 0.1332
CNS manifestation 2 (17) 10 (3) 0.0607
Nausea/vomiting 1 (8) 55 (17) 0.6987
Diarrhea 1 (8) 30 (9) >0.9999
Rash 0 25 (7.5) >0.9999

*Values are no. (%) except as indicated. Bold type indicates statistical significance. CNS, central nervous system; IQR, interquartile range; MRMp, macrolide-resistant Mycoplasma pneumoniae; MSMp, macrolide-sensitive Mycoplasma pneumoniae; PICU, pediatric intensive care unit.

Main Article

1Current affiliation: Marshall University, Huntington, West Virginia, USA.

Page created: March 30, 2021
Page updated: May 18, 2021
Page reviewed: May 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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