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Volume 27, Number 7—July 2021

Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru1

Maria L. Morales, Melinda B. Tanabe, A. Clinton White, Martha Lopez, Ruben Bascope, and Miguel M. CabadaComments to Author 
Author affiliations: Universidad Peruana Cayetano Heredia, Cusco, Peru (M.L. Morales, A.C. White Jr., M. Lopez, M.M. Cabada); University of Texas Medical Branch, Galveston, Texas, USA (M.B. Tanabe, A.C. White Jr., M.M. Cabada); Peruvian Ministry of Health, Cusco (R. Bascope)

Main Article

Table 3

Response to first round of triclabendazole treatment for Fasciola hepatica infection among preschool and school-age children compared with failure to respond to first or fourth round of treatment, Cusco, Peru*

Characteristic Cured after first round, n = 80 Failed after first round, n = 66 p value† Failed after fourth round, n = 17 p value†
Anta 27 (34) 26 (39) 0.48 12 (71) 0.005
53 (64)
40 (61)

5 (29)

Fas2 ELISA result
Negative 27 (35) 12 (18) 0.02 2 (12) 0.08
50 (65)
54 (82)

15 (88)

Likelihood of poverty‡
<50% 56 (70) 56 (89) 0.08 17 (100) 0.03
16 (30)
7 (11)

0 (0)

Other parasites§
No 42 (53) 41 (62) 0.24 11 (65) 0.35
38 (48)
25 (38)

6 (35)

F 44 (55) 33 (50) 0.54 10 (59) 0.77
36 (45)
33 (50)

7 (41)

Age, y, mean ± SD
10.5 ± 2.9
10.4 ± 3.4
9.0 ± 3.6
Baseline egg count, eggs/g of stool 33.3 (6.6–53.3) 48.3 (25–87.5) 0.001 60 (26–100) 0.005
Baseline hemoglobin, g/dL¶ 12.9 (12.1–13.7) 12.9 (12.3–13.4) 0.97 12.3 (12–13) 0.08
Baseline HAZ# −1.6 (−2.2 to −1.0)# −1.5 (−2.0 to −0.9)# 0.19 −1.2 (−1.9 to −0.7) 0.17
Eosinophil count, cells/μL 300 (190–460)# 265 (197–412) 0.36 310 (230–500) 0.64

*Values are no. (%) or median (interquartile range) except as indicated. HAZ, height-for-age Z score. †By Mann-Whitney U test. ‡Likelihood of living under US $3.75/day poverty line (18). §Gastrointestinal parasites. ¶Uncorrected at enrollment. #One or 2 persons were missing information for this variable.

Main Article

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Main Article

1Preliminary results from this study were presented at the 68th Annual Meeting of the American Society of Tropical Medicine and Hygiene, November 20‒24, 2019, National Harbor, MD, USA.

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