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Volume 27, Number 7—July 2021
Research

Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru1

Maria L. Morales, Melinda B. Tanabe, A. Clinton White, Martha Lopez, Ruben Bascope, and Miguel M. CabadaComments to Author 
Author affiliations: Universidad Peruana Cayetano Heredia, Cusco, Peru (M.L. Morales, A.C. White Jr., M. Lopez, M.M. Cabada); University of Texas Medical Branch, Galveston, Texas, USA (M.B. Tanabe, A.C. White Jr., M.M. Cabada); Peruvian Ministry of Health, Cusco (R. Bascope)

Main Article

Table 4

Clinical characteristics of 17 children who failed 4 rounds of triclabendazole treatment for Fasciola hepatica infection among preschool and school-age children, Cusco, Peru*

Child Community District Age, y/sex Other parasites HAZ Living under US $3.75/day ERR, %† Total drug dose, mg/kg‡ Additional treatment received
1 Anta Anta 6.8/F Yes −0.6 25 0§ 90 1 more round
2 Anta Anta 14.1/M No −2.3 25 40 90 2 more rounds
3 Conchacalla Anta 10.5/M No −1.8 13 67 210 Nitazoxanide
4 Conchacalla Anta 3.2/F No −2.4 36 40 50 2 more rounds
5 Conchacalla Anta 6.0/F No −0.4 36 0§ 210 None
6 Inquilpata Anta 8.5/M No −0.9 36 30 50 2 more rounds
7 Inquilpata Anta 9.7/F No −1.2 36 43 50 2 more rounds
8 Inquilpata Anta 3.3/M Yes −1.2 49 +275 210 None
9 Izcuchaca Anta 13.9/F No −0.6 36 +574 150 1 more round
10 Izcuchaca Anta 7.4/M No −0.6 25 63 150 1 more round
11 Mantoclla Anta 7.3/F Yes −2.0 25 10 150 None
12 Mantoclla Anta 9.2/F Yes −1.9 25 31 150 None
13 Caccahuara Ancahuasi 13.1/F No −1.5 25 17 210 Nitazoxanide
14 Caccahuara Ancahuasi 15.5/F No −1.9 13 +50 210 None
15 Caccahuara Ancahuasi 7.8/M No −1.1 25 +100 210 Nitazoxanide
16 Chaquillccasa Ancahuasi 11.5/M Yes −0.9 25 +250 210 None
17 Chaquillccasa Ancahuasi 5.5/F Yes −2.1 49 63 210 1 more round

*ERR, egg reduction rate; HAZ, height-for-age Z score. †Between baseline and after the fourth round of treatment, as estimated by the number of eggs in Kato Katz tests. + signs indicate the percent increase in the egg count. ‡Total cumulative dose received after the fourth round of treatment §Diagnosed only by Lumbreras rapid sedimentation test and a negative Kato Katz test result.

Main Article

1Preliminary results from this study were presented at the 68th Annual Meeting of the American Society of Tropical Medicine and Hygiene, November 20‒24, 2019, National Harbor, MD, USA.

Page created: April 26, 2021
Page updated: June 16, 2021
Page reviewed: June 16, 2021
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