Whole-Genome Analysis of Streptococcus pneumoniae Serotype 4 Causing Outbreak of Invasive Pneumococcal Disease, Alberta, Canada
James D. Kellner
, Leah J. Ricketson, Walter H.B. Demczuk, Irene Martin, Gregory J. Tyrrell, Otto G. Vanderkooi, and Michael R. Mulvey
Author affiliations: University of Calgary, Calgary, Alberta, Canada (J.D. Kellner, L.J. Ricketson, O.G. Vanderkooi); Alberta Health Services, Calgary Zone, Calgary (J.D. Kellner, O.G. Vanderkooi); National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada (W.H.B. Demczuk, I. Martin, M.R. Mulvey); University of Alberta, Edmonton, Alberta (G.J. Tyrrell); Alberta Precision Laboratories–Public Health, Edmonton (G.J. Tyrrell)
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Figure 2
Figure 2. Maximum-likelihood core SNV unrooted phylogenetic tree of 190 Streptococcus pneumoniae serotype 4 isolates collected from patients in Alberta, Canada, 2010–2018. A total of 3,097 sites were used in the phylogeny, and 80.7% of the core genome was included. S. pneumoniae TIGR4 (arrow; National Center for Biotechnology Information accession number NC_003028.3) was used as a mapping reference. Cluster analysis did not group 1 ST205 isolate and TIGR4 with the other clade C strains. SNV, single nucleotide variant; ST, sequence type.
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