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Volume 27, Number 7—July 2021
Research

Fatal Human Infection with Evidence of Intrahost Variation of Eastern Equine Encephalitis Virus, Alabama, USA, 2019

Holly R. HughesComments to Author , Jason O. Velez, Emily H. Davis, Janeen Laven, Carolyn V. Gould, Amanda J. Panella, Amy J. Lambert, J. Erin Staples, and Aaron C. Brault
Author affiliation: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Main Article

Figure 2

Amino acid sequence alignments depicting variation in the eastern equine encephalitis virus from a woman in Alabama, USA, 2019, compared with reference viruses. Open reading frames from 46 eastern equine encephalitis virus complete genomes were translated and aligned with ClustalW (16). Amino acid alignments show variants in the 2019 sequence in the nonstructural protein I251T (A) and structural E2 protein L62S (B). Green shading indicates changes unique to the virus sequence obtained from serum compared with cerebrospinal fluid. Reference viruses are labeled with year of isolation, host, state of isolation, and GenBank accession number.

Figure 2. Amino acid sequence alignments depicting variation in the eastern equine encephalitis virus from a woman in Alabama, USA, 2019, compared with reference viruses. Open reading frames from 46 eastern equine encephalitis virus complete genomes were translated and aligned with ClustalW (16). Amino acid alignments show variants in the 2019 sequence in the nonstructural protein I251T (A) and structural E2 protein L62S (B). Green shading indicates changes unique to the virus sequence obtained from serum compared with cerebrospinal fluid. Reference viruses are labeled with year of isolation, host, state of isolation, and GenBank accession number.

Main Article

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