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Volume 27, Number 8—August 2021
Research Letter

Tuberculosis-Associated Hospitalizations and Deaths after COVID-19 Shelter-In-Place, San Francisco, California, USA

Janice K. LouieComments to Author , Rocio Agraz-Lara, Laura Romo, Felix Crespin, Lisa Chen1, and Susannah Graves1
Author affiliations: San Francisco Department of Public Health Tuberculosis Prevention and Control Program, San Francisco, California, USA (J.K. Louie, R. Agraz-Lara, L. Romo, F. Crespin, S. Graves); University of California, San Francisco (J.K. Louie, L. Chen)

Main Article


New diagnoses of TB pre-SIP compared with during SIP during the coronavirus disease pandemic, San Francisco, California, USA, January 1, 2020–January 30, 2021*

Variable Pre-SIP: 2019 Jan 1–2020 Mar 15 SIP: 2020 Mar 16–2021 Jan 30 p value†
New diagnoses of active TB 114 (100) 52 (100)‡ NA
Average no. new TB cases/month 7.9 5.0 NA
Median age of case-patients, y (range) 64.0 (3–101) 66.0 (15–97) NS
New case-patients with cavitary TB 33 (28.9) 11 (21.2) NS
New TB case-patients requiring hospitalization 38 (33.3) 33 (63.5) 0.0003
New TB case-patients requiring intensive care 5 (4.4) 12 (23.1) 0.0002
New TB case-patients who died 15 (13.2) 10 (19.2) NS
New TB case-patients with TB-related deaths§ 4 (3.5) 7 (13.5) 0.017

*Values are no. (%) unless indicated. Cases were counted according to the month when TB was diagnosed. NA, not applicable; NS, not significant (p>0.05); SIP, shelter-in-place; TB, tuberculosis. †By Pearson χ2 test. ‡All patients were tested for severe acute respiratory syndrome coronavirus 2 co-infection at time of TB diagnosis, except for 7 patients for whom testing was not routinely available in the first 3 months of the pandemic (March–May 2020); no patients were positive. §Cause of death was evaluated by standardized algorithm and review of medical records and death certificate, when available. Deaths were counted as TB-related when TB was assessed as an immediate or contributing cause of death.

Main Article

1These senior authors contributed equally to this article.

Page created: June 11, 2021
Page updated: July 19, 2021
Page reviewed: July 19, 2021
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