Predictors of Nonseroconversion after SARS-CoV-2 Infection
, Ronnie M. Russell1
, Frederic Bibollet-Ruche1
, Ashwin N. Skelly1
, Scott Sherrill-Mix1
, Drew A. Freeman1
, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J. Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E. Hensley, Thomas Ketas, Albert Cupo, Victor M. Cruz Portillo, John P. Moore, Paul D. Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard2
, Michael S. Saag, Randall S. Davis, George M. Shaw, William J. Britt, Sixto M. Leal, Paul Goepfert, and Beatrice H. Hahn
Author affiliations: University of Pennsylvania, Philadelphia, Pennsylvania, USA (W. Liu, R.M. Russell, F. Bibollet-Ruche, A.N. Skelly, S. Sherrill-Mix, R. Stoltz, E. Lindemuth, F.-H. Lee, K.J. Bar, S. Gouma, S.E. Hensley, G.M. Shaw, B.H. Hahn); The University of Alabama at Birmingham, Birmingham, Alabama, USA (D.A. Freeman, S. Sterrett, N. Erdmann, M.S. Saag, R.S. Davis, W.J. Britt, S.M. Leal Jr., P. Goepfert); Weill Cornell Medicine, New York, New York, USA (T. Ketas, A. Cupo, V.M. Cruz Portillo, J.P. Moore); Howard Hughes Medical Institute, New York (P.D. Bieniasz); The Rockefeller University, New York (P.D. Bieniasz, T. Hatziioannou); Assurance Scientific, Vestavia, Alabama, USA (G. Massey, M.-B. Minyard)
Figure 1. Relationship of age and nasopharyngeal viral loads with SARS-CoV-2 serostatus among convalescent persons after SARS-CoV-2 infection. Participants were a convenience sample of convalescent SARS-CoV-2–infected persons recruited at the University of Alabama at Birmingham, Birmingham, Alabama, USA, 2020. Age (panels A, C, and E) and RT-PCR Ct values (panels B, D, and F) are plotted for seropositive (red) and seronegative (blue) persons. Panels show comparisons of persons tested at all sites (panels A, B), the Assurance Scientific Laboratories site (panels B, C), and the University of Alabama at Birmingham Fungal Reference Laboratory and Children’s of Alabama Diagnostic Virology Laboratory sites (panels E, F). The mean (horizontal line) and corresponding 95% CI (shading) are shown; p-values indicate the results of a likelihood ratio test after Bonferroni correction for multiple comparisons. Ct, cycle threshold; RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
Page created: June 30, 2021
Page updated: August 18, 2021
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