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Volume 28, Number 1—January 2022

Dispatch

SARS-CoV-2 RNA Shedding in Semen and Oligozoospermia of Patient with Severe Coronavirus Disease 11 Weeks after Infection

Lawrence J. PurpuraComments to Author , Joseph Alukal, Alexander M. Chong, Lihong Liu, Anyelina Cantos, Jayesh Shah, Nicola Medrano, Jennifer Y. Chang, Moriya Tsuji, Hiroshi Mohri, Anne Catrin Uhlemann, David Ho, and Michael T. Yin
Author affiliations: Columbia Mailman School of Public Health, New York, New York, USA (L.J. Purpura); Columbia University Irving Medical Center, New York (L.J. Purpura, J. Alukal, A.M. Chong, L. Liu, A. Cantos, J. Shah, N. Medrano, J.Y. Chang, M. Tsuji, H. Mohri, A.C. Uhlemann, D. Ho, M.T. Yin)

Main Article

Table 2

RT-PCR and serologic test results for participant 1 who was infected with SARS-CoV-2 in longitudinal prospective coronavirus disease cohort study, New York, USA*

Days after symptom onset Sample PCR result, Ct Binding antibody EC50, NP/S Neutralizing antibody IC50 T cell reactivity against M protein, IFN-γ‒secreting T cells/million PBMCs†
72 Saliva Negative
72
 Blood
 Negative
 1,351/3,728 (modest)
 (modest)
78
 Saliva
 Negative
78
 Stool
 Negative
78
 Blood
 Negative
 1,756/5,680 (modest)
 (modest)
81
 Semen
 Positive, 34.79
81
 Blood
 NT
>130 (strong)
81
 Saliva
 Negative
101
 Semen
 Negative
101
 Saliva
 Negative
101
 Stool
 Negative
169
 Saliva
 Negative
169 Stool Negative
169 Semen Negative

*Ct, cycle threshold; EC50, concentration half of the maximum effect; IC50, half-maximal inhibitory concentration; IFN, interferon; NP, nucleocapsid protein; NT, not tested; PBMCs, peripheral blood mononuclear cells; S, spike protein; SARS-CoV 2, severe acute respiratory syndrome coronavirus 2.

Main Article

Page created: October 01, 2021
Page updated: December 20, 2021
Page reviewed: December 20, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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