Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 10—October 2022
Research Letter

Sindbis Virus Antibody Seroprevalence in Central Plateau Populations, South Africa

Nicole Kennedy, Dominique Goedhals, Sabeehah Vawda, Philip Armand Bester, and Felicity BurtComments to Author 
Author affiliations: University of the Free State, Bloemfontein, South Africa (N. Kennedy, D. Goedhals, S. Vawda, P.A. Bester, F. Burt); National Health Laboratory Service, Bloemfontein, South Africa (D. Goedhals, S. Vawda, P.A. Bester, F. Burt)

Main Article


Sindbis virus–specific IgG and neutralizing antibodies in patient serum samples in study of Sindbis virus antibody seroprevalence in central plateau populations, South Africa*

Patient group Collection period, y Patient samples
No. IgG+/no. tested per group (%) % IgG+ of total tested No. IgG+/total IgG+ (%) No. NA+/no. IgG+ tested
Patients attending rheumatology clinic 2013–2017 31/165 (18.8) 5.5 31/69 (44.9) 29/31
High-risk populations† 2016–2017 13/136 (9.6) 2.3 13/69 (18.8) 13/13
Patients with AFI, no diagnosis
2007– 2010
25/267 (9.4)
25/69 (36.2)
Total no. patients 69/568 12.2 65/69

*We used an in-house ELISA to measure Sindbis virus–specific IgG and a 50% tissue culture infectious dose serum neutralization assay to measure Sindbis virus neutralizing antibodies in patient serum samples. AFI, acute febrile illness; NA, neutralizing antibody; +, positive. †Residents of Sindbis virus-endemic regions.

Main Article

Page created: August 16, 2022
Page updated: September 21, 2022
Page reviewed: September 21, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.