Skip directly to page options Skip directly to A-Z link
Volume 28, Number 11—November 2022
Research Letter

TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

Pimpayao Sodsai1, Chupong Ittiwut1, Vichaya Ruenjaiman, Rungnapa Ittiwut, Watsamon Jantarabenjakul, Kanya Suphapeetiporn, Vorasuk Shotelersuk2Comments to Author , and Nattiya Hirankarn2
Author affiliations: Chulalongkorn University, Bangkok, Thailand (P. Sodsai, C. Ittiwut, V. Ruenjaiman, R. Ittiwut, W. Jantarabenjakul, K. Suphapeetiporn, V. Shotelersuk, N. Hirankarn); King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok (W. Jantarabenjakul, R. Ittiwut)

Main Article

Figure

Results of rRT-PCR assay and flow cytometry of TIGIT nonsense variant in a patient with severe COVID-19 infection, Thailand. Co45 is the patient with TIGIT nonsense variant; Co84 and Co6 are age- and sex-matched patients who also had severe COVID-19 infection. A) Mean relative mRNA levels of TIGIT expression from rRT-PCR assay. B) TIGIT expression MFI on CD3+ T cells. C) TIGIT expression MFI on CD4+ T cells. D) TIGIT expression MFI on CD8+ T cells. CD, cytoplasmic domain; MFI, mean fluorescence intensity; rRT-PCR, real-time reverse transcription PCR; TIGIT, T cell immunoglobulin and ITIM domain gene.

Figure. Results of rRT-PCR assay and flow cytometry of TIGIT nonsense variant in a patient with severe COVID-19 infection, Thailand. Co45 is the patient with TIGIT nonsense variant; Co84 and Co6 are age- and sex-matched patients who also had severe COVID-19 infection. A) Mean relative mRNA levels of TIGIT expression from rRT-PCR assay. B) TIGIT expression MFI on CD3+ T cells. C) TIGIT expression MFI on CD4+ T cells. D) TIGIT expression MFI on CD8+ T cells. CD, cytoplasmic domain; MFI, mean fluorescence intensity; rRT-PCR, real-time reverse transcription PCR; TIGIT, T cell immunoglobulin and ITIM domain gene.

Download

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

Page created: September 20, 2022
Page updated: October 24, 2022
Page reviewed: October 24, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external