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Volume 28, Number 11—November 2022

Research Letter

TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

Pimpayao Sodsai1, Chupong Ittiwut1, Vichaya Ruenjaiman, Rungnapa Ittiwut, Watsamon Jantarabenjakul, Kanya Suphapeetiporn, Vorasuk Shotelersuk2Comments to Author , and Nattiya Hirankarn2
Author affiliations: Chulalongkorn University, Bangkok, Thailand (P. Sodsai, C. Ittiwut, V. Ruenjaiman, R. Ittiwut, W. Jantarabenjakul, K. Suphapeetiporn, V. Shotelersuk, N. Hirankarn); King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok (W. Jantarabenjakul, R. Ittiwut)

Main Article

Figure

Results of rRT-PCR assay and flow cytometry of TIGIT nonsense variant in a patient with severe COVID-19 infection, Thailand. Co45 is the patient with TIGIT nonsense variant; Co84 and Co6 are age- and sex-matched patients who also had severe COVID-19 infection. A) Mean relative mRNA levels of TIGIT expression from rRT-PCR assay. B) TIGIT expression MFI on CD3+ T cells. C) TIGIT expression MFI on CD4+ T cells. D) TIGIT expression MFI on CD8+ T cells. CD, cytoplasmic domain; MFI, mean fluorescence intensity; rRT-PCR, real-time reverse transcription PCR; TIGIT, T cell immunoglobulin and ITIM domain gene.

Figure. Results of rRT-PCR assay and flow cytometry of TIGIT nonsense variant in a patient with severe COVID-19 infection, Thailand. Co45 is the patient with TIGIT nonsense variant; Co84 and Co6 are age- and sex-matched patients who also had severe COVID-19 infection. A) Mean relative mRNA levels of TIGIT expression from rRT-PCR assay. B) TIGIT expression MFI on CD3+ T cells. C) TIGIT expression MFI on CD4+ T cells. D) TIGIT expression MFI on CD8+ T cells. CD, cytoplasmic domain; MFI, mean fluorescence intensity; rRT-PCR, real-time reverse transcription PCR; TIGIT, T cell immunoglobulin and ITIM domain gene.

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

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