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Volume 28, Number 12—December 2022
Research Letter

Severe Human Case of Zoonotic Infection with Swine-Origin Influenza A Virus, Denmark, 2021

Klara M. AndersenComments to Author , Lasse S. Vestergaard, Jakob N. Nissen, Sophie J. George, Pia Ryt-Hansen, Charlotte K. Hjulsager, Jesper S. Krog, Marianne N. Skov, Søren Alexandersen, Lars E. Larsen, and Ramona Trebbien
Author affiliations: Technical University of Denmark, Kongens Lyngby, Denmark (K.M. Andersen); Statens Serum Institut, Copenhagen, Denmark (K.M. Andersen, L.S. Vestergaard, J.N. Nissen, C.K. Hjulsager, J.S. Krog, S. Alexandersen, R. Trebbien); University of Copenhagen, Copenhagen (S.J. George, P. Ryt-Hansen, L.E. Larsen); Odense University Hospital, Odense, Denmark (M.N. Skov)

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Table

Percentage nucleotide and amino acid identities between influenza A virus from a patient in Denmark (A/Denmark/36/2021), the seasonal vaccine strain, and closely related strains*

Gene A/Victoria/2570/2019 A/swine/Denmark/S19922-5/2021 A/swine/Denmark/24856-3/2021 A/swine/Denmark/S22282-5/2021 A/Denmark/1/2021
Pairwise nucleotide identity to A/Denmark/36/2021, %
PB2 94.8 99.4 98.9 99.4 96.1
PB1 94.7 99.5 98.9 99.3 93.6
PA 95.2 99.8 99.3 99.6 96.8
HA 90.7 99.0 98.7 72.6 89.9
NP 95.3 99.7 98.9 99.4 96.4
NA 86.9 99.3 98.7 n/a 87.0
MP 95.2 99.6 99.6 92.6 95.3
NS
79.7
99.9
99.1
99.6
92.8
Pairwise amino acid identity to A/Denmark/36/2021, %
PB2 97.2 99.6 99.5 99.6 97.9
PB1 97.6 99.9 99.5 99.9 97.9
PA 97.6 99.9 99.3 99.4 98.3
PA-X 96.6 100 100 100 98.7
HA 90.3 98.8 98.6 75.8 88.5
NP 98.2 100 99.6 99.8 98.4
NA 85.1 98.9 97.4 n/a 86.1
M1 97.6 100 100 97.6 97.6
M2 94.9 100 100 90.7 93.8
NS1 72.4 99.6 98.3 99.1 91.7
NEP 85.1 100 100 100 95

*Seasonal vaccine strain, A/Victoria/2570/2019 (GISAID isolate no. EPI_ISL_517733; Appendix 2; strains from passive surveillance Denmark: A/swine/Denmark/S19922–5/2021 (GenBank accession nos. ON716251–8), A/swine/Denmark/24856-3/2021 (accession nos. ON716275–82), A/Denmark/S22282-5/2021 (accession nos. ON716267–74); and another recent variant case found in Denmark (A/Denmark/1/2021; GISAID isolate no. EPI_ISL_909652) (4). The A/swine/Denmark/S22282-5/2021 is of the H1N2 subtype and therefore no percentage similarity is reported to the neuraminidase gene segment and protein of this strain. HA, hemagglutinin; MP/M1/M2, matrix protein 1/2; NA, neuraminidase; n/a, not applicable; NEP, nuclear export protein; NP, nucleoprotein; NS/NS1, nonstructural protein; PA, polymerase acidic protein; PB1/2, polymerase basic protein 1/2.

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References
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