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Volume 28, Number 2—February 2022

Invasive Burkholderia cepacia Complex Infections among Persons Who Inject Drugs, Hong Kong, China, 2016–2019

Kristine Shik Luk, Yat-ming TsangComments to Author , Alex Yat-man Ho, Wing-kin To, Ben Kwok-ho Wong, Maureen Mo-lin Wong, and Yiu-chung Wong
Author affiliations: Princess Margaret Hospital, Hong Kong, China (K.S. Luk, Y.M. Tsang, A.Y.M. Ho, W.K. To); Caritas Medical Centre, Hong Kong (B.K.H. Wong, M.M.L Wong); Yan Chai Hospital, Hong Kong (Y.C. Wong)

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Table 2

Laboratory and microbiological findings, treatments, and outcomes of invasive infections caused by Burkholderia cepacia complex in persons who inject drugs, Hong Kong, China, 2016–2019*

Median leukocytes, × 109 cells/L (range)
9.2 (3.94–24.7)
Median ESR, mm/h (range)
79.5 (43 to >120)
Median CRP, mg/L (range)
68 (21 to >294)
Empirical antimicrobial therapy (no. patients)
Amoxicillin/clavulanate (10); cloxacillin (3); vancomycin (2); ampicillin, cefoperazone/sulbactam, gentamicin, piperacillin/tazobactam (1)
Definitive antimicrobial therapy (no. patients)
Trimethoprim/sulfamethoxazole (6); ceftazidime (5); levofloxacin (5); meropenem (2); minocycline, piperacillin/tazobactam (1)
Median duration of antimicrobial therapy (range), wk
6 (1–12)
Surgery (no. patients)
Vertebral disk excision (3), incision and drainage (1), spinal fusion† (3), joint arthrotomy (2), excisional arthroplasty (1)
Positive culture (no. patients)
Bone (5), blood† (4), intervertebral disk (3), abscess (2), joint fluid (1)
Median length of stay (range), d
43 (11 – 97)
Death (d after first visit) Patient 3 (124); patient 4 (13)

*CRP, C-reactive protein; ESR, erythrocyte sedimentation rate. †Patient 2 had a relapse of Burkholderia cepacia complex infective spondylitis 5 mo after receiving meropenem and oral trimethoprim/sulfamethoxazole for 6 wk; spinal fusion was performed during the relapse episode.

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Page created: December 02, 2021
Page updated: January 22, 2022
Page reviewed: January 22, 2022
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