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Volume 28, Number 2—February 2022
Dispatch

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K. Taubenberger, Matthew J. Memoli, Kaitlyn Sadtler, Patrick E. Duffy, and Fabiano OliveiraComments to Author 
Author affiliations: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA (J. Manning, I. Zaidi, C. Lon, L.A. Rosas, J.-K. Park, A. Ponce, J. Bohl, J.K. Taubenberger, M.J. Memoli, P.E. Duffy, F. Oliveira); National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia (S. Chea, S. Sreng, H. Rekol, C.M. Chour); National Institute of Biomedical Imaging and Bioengineering, Bethesda (M. Karkanitsa, K. Sadtler); Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA (D. Esposito)

Main Article

Table

SARS-CoV-2 ELISA results by cutoff values in prepandemic serum samples from rural malaria-experienced persons in 3 Cambodia provinces, 2005–2011*

Province Year Total No. positive by 2 SDs No. positive by 3 SDs No. positive, Mali
Preah Vihear
 2011
 81
 12 (15)
 6 (7)
 5 (6)
Pursat 2005 80 8 (10) 4 (5) 3 (4)
2009 76 12 (16) 6 (8) 3 (0.9)
2010 81 5 (6) 3 (4) 1 (0.3)
2011 110 17 (15.5) 12 (11) 6 (5.4)
Subtotal
 347
 42 (12)
 25 (7)
 13 (3.7)
Ratanakiri
 2011
 100
 19 (19)
 6 (6)
 5 (5)
Total All 528 73 (13.8) 37 (7) 23 (4.4)

*Values are no. (%) except as indicated. Using United States arbitrary ELISA unit cutoffs of 2 SDs for spike (0.674) and receptor binding domain (RBD) (0.306); United States 3 SDs for spike (0.910) and RBD (0.387); and Mali cutoff for spike (0.791) and RBD (1.183). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Main Article

Page created: December 02, 2021
Page updated: January 22, 2022
Page reviewed: January 22, 2022
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