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Volume 28, Number 2—February 2022
Research Letter

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, November 2021

Haogao Gu, Pavithra Krishnan, Daisy Y.M. Ng, Lydia D.J Chang, Gigi Y.Z. Liu, Samuel S.M. Cheng, Mani M.Y. Hui, Mathew C.Y. Fan, Jacob H.L. Wan, Leo H.K. Lau, Benjamin J. Cowling, Malik Peiris, and Leo L.M. PoonComments to Author 
Author affiliation: The University of Hong Kong, Hong Kong, China

Main Article

Figure

Detection of severe acute respiratory syndrome coronavirus 2 Omicron variant in 2 patients (cases A and B) in Hong Kong, China, November 2021. A) Phylogenetic time tree of Omicron nucleotide sequences using an early severe acute respiratory syndrome coronavirus sequence as a reference sequence (Wuhan-Hu-1/2019; GenBank accession no. MN908947.3). B) Comparison of Omicron variant mutations in case A to other variants; red indicates VOC and gray VOI (Appendix). Text colors indicate mutations found in NTD (blue), RBD (orange), FP (purple), and HR1 (green). Lane 1, case A; 2, Alpha (B.1.1.7); 3, Beta (B.1351); 4, Delta (B.1.617.2); 5, Gamma (P1); 6, Epsilon (B.1.427/429); 7, Eta (B.1.525); 8, Iota (B.1.526); 9, Kappa (B.1.617.1); 10, Lambda (C.37); 11, Mu (B.1.1.621); 12, Theta (P.3); 13, Zeta (P.2). E, envelope; FP, fusion peptide; HR1, heptad repeat 1; M, matrix; NSP, nonstructural protein; NTD, N-terminal domain; RBD, receptor-binding domain; S, spike; VOC, variant of concern; VOI, variant of interest.

Figure. Detection of severe acute respiratory syndrome coronavirus 2 Omicron variant in 2 patients (cases A and B) in Hong Kong, China, November 2021. A) Phylogenetic time tree of Omicron nucleotide sequences using an early severe acute respiratory syndrome coronavirus sequence as a reference sequence (Wuhan-Hu-1/2019; GenBank accession no. MN908947.3). B) Comparison of Omicron variant mutations in case A to other variants; red indicates VOC and gray VOI (Appendix). Text colors indicate mutations found in NTD (blue), RBD (orange), FP (purple), and HR1 (green). Lane 1, case A; 2, Alpha (B.1.1.7); 3, Beta (B.1351); 4, Delta (B.1.617.2); 5, Gamma (P1); 6, Epsilon (B.1.427/429); 7, Eta (B.1.525); 8, Iota (B.1.526); 9, Kappa (B.1.617.1); 10, Lambda (C.37); 11, Mu (B.1.1.621); 12, Theta (P.3); 13, Zeta (P.2). E, envelope; FP, fusion peptide; HR1, heptad repeat 1; M, matrix; NSP, nonstructural protein; NTD, N-terminal domain; RBD, receptor-binding domain; S, spike; VOC, variant of concern; VOI, variant of interest.

Main Article

Page created: December 01, 2021
Page updated: January 23, 2022
Page reviewed: January 23, 2022
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