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Volume 28, Number 3—March 2022
Dispatch

Ebola Virus Glycoprotein IgG Seroprevalence in Community Previously Affected by Ebola, Sierra Leone

Daniela MannoComments to Author , Philip Ayieko, David Ishola, Muhammed O. Afolabi, Baimba Rogers, Frank Baiden, Alimamy Serry-Bangura, Osman M. Bah, Brian Köhn, Ibrahim Swaray, Kwabena Owusu-Kyei, Godfrey T. Otieno, Dickens Kowuor, Daniel Tindanbil, Elizabeth Smout, Cynthia Robinson, Babajide Keshinro, Julie Foster, Katherine Gallagher, Brett Lowe, Macaya Douoguih, Bailah Leigh, Brian Greenwood, and Deborah Watson-Jones
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (D. Manno, P. Ayieko, D. Ishola, M.O. Afolabi, F. Baiden, B. Köhn, K. Owusu-Kyei, G.T. Otieno, D. Kowuor, D. Tindanbil, E. Smout, J. Foster, K. Gallagher, B. Lowe, B. Greenwood, D. Watson-Jones); Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania (P. Ayieko, D. Watson-Jones); University of Sierra Leone College of Medicine and Allied Health Sciences, Freetown, Sierra Leone (B. Rogers, A. Serry-Bangura, O.M. Bah, I. Swaray, B. Leigh); Janssen Vaccines and Prevention, Leiden, the Netherlands (C. Robinson, B. Keshinro, M. Douoguih)

Main Article

Table 1

Potential EVD exposure in community or work during the 2014–2016 EVD outbreak and antibody seropositivity and GMC among participants in a study of EBOV GP–specific binding antibody seropositivity, Sierra Leone*

Risk factors No. (%), n = 1,282 No. seropositive/ no. tested (%) OR (95% CI) Adjusted OR
(95% CI)†		 GMC, EU/mL (95% CI) GMC ratio (95% CI) Adjusted GMC
ratio (95% CI)†
Living in a village or town with Ebola cases, n = 1,281
N 199 (15.5) 10/198 (5.1) Referent,
p = 0.049		 Referent,
p = 0.125		 49 (40–58) Referent,
p = 0.010		 Referent,
p = 0.882
Y
 1,082 (84.5)
 97/1,073 (9.0)
 1.9 (1.0–3.6)
 1.7 (0.8–3.3)
 65 (60–71)
 1.3 (1.1–1.6)
 1.0 (0.8–1.3)
Knowing someone who had Ebola
No, don't know 1,044 (81.4) 82/1,036 (7.9) Referent,
p = 0.193		 61, 56–67) Referent,
p = 0.204
Y
 238 (18.6)
 25/236 (10.6)
 1.4 (0.9–2.2)
70 (57–85)
 1.1 (0.92–1.4)
No. EVD cases known by participant
0 1,044 (81.4) 82/1,036 (7.9) Referent,
p = 0.55		 61 (56–67) Referent,
p = 0.382
1 125 (9.8) 13/125 (10.4) 1.4 (0.7–2.5) 64 (49–85) 1.1 (0.8–1.4)
2–3 66 (5.2) 8/65 (12.3) 1.6 (0.8–3.5) 84 (57–124) 1.4 (0.9–2.0)
>3
 47 (3.7)
 4/46 (8.7)
 1.1 (0.4–3.2)
66 (44–99)
 1.1 (0.7–1.6)
Closest relationship with an EVD case, n = 1,280
No relationship‡ 1,044 (81.5) 82/1,036 (7.9) Referent,
p = 0.197		 61, 56–67) Referent,
p = 0.259
Close family§ 27 (2.1) 1/27 (3.7) 0.5 (0.1–3.3) 52 (33–81) 0.9 (0.5–1.3)
Other relative 52 (4.1) 6/51 (11.8) 1.6 (0.6–3.7) 64 (42–96) 1.0 (0.7–1.6)
Friend 59 (4.6) 4/59 (6.8) 0.8 (0.3–2.4) 64 (45–91) 1.1 (0.7–1.5)
Community member
 98 (7.7)
 14/97 (14.4)
 2.0 (1.1–3.7)
86 (62–120)
 1.4 (1.0–2.0)
Living in the same household with an EVD case, n = 1,280
N 1,269 (99.1) 107/1,260 (8.5) – 63 (58–68) Referent,
p = 0.814
Y
 11 (0.9)
 0/10 (0.0)
 –
56 (31–102)
 0.9 (0.5–1.6)
Caring for an EVD case, n = 1,281
N 1,272 (99.3) 107/1,262 (8.5) – 63 (58–68) Referent,
p = 0.600
Y
 9 (0.7)
 0/9 (0.0)
 –
48 (24–98)
 0.8 (0.4–1.6)
Direct body contact with an EVD case, n = 1,281
N 1,275 (99.5) 107/1,265 (8.5) – 62 (57–67) Referent,
p = 0.640
Y
 6 (0.5)
 0/6 (0.0)
 –
83 (28–242)
 1.3 (0.5–3.9)
Attending a funeral of an EVD case
N 1,263 (98.5) 105/1,254 (8.4) Referent,
p = 0.691		 62 (57–67) Referent,
p = 0.346
Y
 19 (1.5)
 2/18 (11.1)
 1.4 (0.3–6.0)
87 (37–204)
 1.4 (0.6–3.3)
Healthcare frontline worker during EVD outbreak
No, NA¶ 1,254 (97.8) 105/1,244 (8.4) Referent,
p = 0.802		 63 (58–69) Referent,
p = 0.798
Y 28 (2.2) 2/28 (7.1) 0.8 (0.2–3.6) 58 (36–93) 0.9 (0.6–1.5)

*Seropositivity defined as >607 EU/mL. EBOV GP–specific binding antibodies were indeterminate in 10 participants. p values calculated by using likelihood ratio test. EBOV GP, Ebola virus glycoprotein; EU, ELISA units; EVD, Ebola virus disease; GMC, geometric mean concentration; NA, not applicable; OR, odds ratio. †Adjusted for age and sex. ‡Participant did not know anyone with Ebola. §Participant was the parent or child or spouse or sibling of an EVD case. ¶Not applicable because participant was a child or did not have a job.

Main Article

Page created: February 06, 2022
Page updated: February 22, 2022
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