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Volume 28, Number 3—March 2022
Dispatch

Ebola Virus Glycoprotein IgG Seroprevalence in Community Previously Affected by Ebola, Sierra Leone

Daniela MannoComments to Author , Philip Ayieko, David Ishola, Muhammed O. Afolabi, Baimba Rogers, Frank Baiden, Alimamy Serry-Bangura, Osman M. Bah, Brian Köhn, Ibrahim Swaray, Kwabena Owusu-Kyei, Godfrey T. Otieno, Dickens Kowuor, Daniel Tindanbil, Elizabeth Smout, Cynthia Robinson, Babajide Keshinro, Julie Foster, Katherine Gallagher, Brett Lowe, Macaya Douoguih, Bailah Leigh, Brian Greenwood, and Deborah Watson-Jones
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (D. Manno, P. Ayieko, D. Ishola, M.O. Afolabi, F. Baiden, B. Köhn, K. Owusu-Kyei, G.T. Otieno, D. Kowuor, D. Tindanbil, E. Smout, J. Foster, K. Gallagher, B. Lowe, B. Greenwood, D. Watson-Jones); Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania (P. Ayieko, D. Watson-Jones); University of Sierra Leone College of Medicine and Allied Health Sciences, Freetown, Sierra Leone (B. Rogers, A. Serry-Bangura, O.M. Bah, I. Swaray, B. Leigh); Janssen Vaccines and Prevention, Leiden, the Netherlands (C. Robinson, B. Keshinro, M. Douoguih)

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Table 2

Potential risk factors for transmission of Ebola virus from animals during the 2014–2016 EVD outbreak and antibody seropositivity and GMC among participants in a study of EBOV GP–specific binding antibody seropositivity, Sierra Leone*

Risk factors No. (%),
n = 1,282		 No. seropositive/ no. tested (%) OR (95% CI) Adjusted OR (95% CI)† GMC, EU/mL (95% CI) GMC ratio (95% CI) Adjusted GMC
ratio (95% CI)†
Number of domestic animals in the participant’s compound
0 503 (39.2) 45/498 (9.0) Referent,
p = 0.558		 59 (51–67) Referent,
p = 0.462
1–5 374 (29.2) 33/371 (8.9) 1.0 (0.6–1.6) 65 (55–75) 1.1 (0.9–1.3)
>5
 405 (31.6)
 29/403 (7.2)
 0.8 (0.5–1.3)
66 (57–76)
 1.1 (0.9–1.3)
Having the following domestic animals in the compound‡
Dog
N 1,116 (87.1) 90/1,107 (8.1) Referent,
p = 0.349		 66 (52–84) Referent,
p = 0.559
Y 165 (12.9) 17/164 (10.4) 1.3 (0.8–2.3) 62 (57–67) 1.1 (0.8–1.4)
Cat
N 951 (74.2) 80/943 (8.5) Referent,
p = 0.887		 61 (56–67) Referent,
p = 0.400
Y 330 (25.8) 27/328 (8.2) 1.0 (0.6–1.5) 66 (56–78) 1.1 (0.9–1.3)
Goat, sheep
N 870 (67.9) 76/863 (8.8) Referent,
p = 0.465		 62 (56–68) Referent,
p = 0.781
Y 411 (32.1) 31/408 (7.6) 0.9 (0.6–1.3) 62 (57–67) 1.0 (0.9–1.2)
Pig
N 1,263 (98.6) 102/1,253 (8.1) Referent,
p = 0.015		 Referent,
p = 0.014		 61 (57–67) Referent, p<0.001 Referent,
p = 0.001
Y 18 (1.4) 5/18 (27.8) 4.3 (1.5–12.4) 4.5 (1.6–13.0) 200 (93–431) 3.3 (1.5–7.1) 3.0 (1.5–5.9)
Other
N 825 (64.4) 73/817 (8.9) Referent,
p = 0.370		 61 (55–68) Referent,
p = 0.513
Y
 456 (35.6)
 34/454 (7.5)
 0.8 (0.5–1.3)
65 (57–74)
 1.1 (0.9–1.3)
Touching sick or dead domestic animals
N 1,253 (97.7) 106/1,243(8.5) Referent,
p = 0.275		 63 (58–68) Referent,
p = 0.824
Y
 29 (2.3)
 1/29 (3.5)
 0.4 (0.1–2.8)
59 (36–97)
 0.9 (0.6–1.6)
Hunting for wild animals§
N 1,261 (99.3) 105/1,251(8.4) Referent,
p = 0.779		 63 (58–68) Referent,
p = 0.859
Y
 9 (0.7)
 1/9 (11.1)
 1.4 (0.2–11.0)
57 (17–191)
 0.9 (0.3–3.1)
Touching sick or dead wild animals
N 1,277 (99.6) 106/1,267 (8.4) Referent,
p = 0.419		 62 (58–68) Referent,
p = 0.825
Y
 5 (0.4)
 1/5 (20.0)
 2.7 (0.3–24.7)
54 (8–369)
 0.9 (0.1–5.9)
Consuming bushmeat
N 1,275 (99.4) 106/1,265 (8.4) Referent,
p = 0.606		 62 (58–68) Referent,
p = 0.962
Y 7 (0.6) 1/7(14.3) 1.8 (0.2–15.3) 61 (14–274) 1.0 (0.2–4.4)

*Seropositivity defined as >607 EU/mL. EBOV GP–specific binding antibodies were indeterminate in 10 participants. p values calculated by using likelihood ratio test. EBOV, Ebola virus; EU, ELISA units; GMC, geometric mean concentration; GP, glycoprotein; OR, odds ratio. †Adjusted for age and sex. ‡Participants could indicate >1 type of domestic animal. §Types of wild animals hunted by participants who answered yes included monkeys, duiker antelopes, bats, and rodents.

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Page created: February 06, 2022
Page updated: February 22, 2022
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