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Volume 28, Number 3—March 2022
Research

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions from Persons with Symptomatic Malaria Infection in Ethiopia, Kenya, Madagascar, and Rwanda

Eric RogierComments to Author , Jessica N. McCaffery, Doug Nace, Samaly Souza Svigel, Ashenafi Assefa, Jimee Hwang, Simon Kariuki, Aaron M. Samuels, Nelli Westercamp, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Aline Uwimana, Venkatachalam Udhayakumar, and Eric S. Halsey
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, J.N. McCaffery, D. Nace, S.S. Svigel, A.M. Samuels, N. Westercamp, V. Udhayakumar); Ethiopia Public Health Institute, Addis Ababa, Ethiopia (A. Assefa); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J. Hwang, E.S. Halsey); Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya (S. Kariuki); Centers for Disease Control and Prevention, Kisumu (A.M. Samuels); Madagascar National Malaria Control Program, Antananarivo, Madagascar (A. Ratsimbasoa); Institut Pasteur de Madagascar, Antananarivo (M. Randrianarivelojosia); Université de Toliara, Toliara, Madagascar (M. Randrianarivelojosia); Rwanda Biomedical Center, Kigali, Rwanda (A. Uwimana)

Main Article

Table 2

Plasmodium falciparum malaria–infected participant DBS samples with atypical HRP2 levels selected for further genomic assays, Ethiopia, Kenya, Madagascar, and Rwanda*

Country and study site No. specimens
at enrollment No. specimens selected for genetic assays (%) No. selected on pAldolase ratio only No. selected on pLDH ratio only No. selected on ratio to both
Ethiopia 147 21 (14.3) 4 7 10
Arba Minch 15 2 (13.3) 1 1 0
Pawe
 132
 19 (14.4)
 3
 6
 10
Kenya
Siaya
 332
 7 (2.1)
 1
 1
 5
Madagascar 620 25 (4.0) 7 10 8
Ankazomborona 168 11 (6.5) 4 2 5
Antsenavolo 54 6 (11.1) 2 4 0
Kianjavato 116 1 (0.9) 0 1 0
Matanga 172 3 (1.7) 0 2 1
Vohitromby
 110
 4 (3.6)
 1
 1
 2
Rwanda 218 16 (7.3) 5 6 5
Bugarama 88 9 (10.2) 2 4 3
Masaka 42 2 (4.8) 0 1 1
Rukara 88 5 (5.6) 3 1 1

*DBS, dried blood spot; HRP2, histidine-rich protein 2; pAldolase, pan-Plasmodium aldolase; pLDH, pan-Plasmodium lactate dehydrogenase.

Main Article

Page created: January 12, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
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