Figure 1. Sensitivity of severe acute respiratory syndrome coronavirus 2 serologic assays (descriptions in Table 1) using 3 definitions of a true positive in study of commercially available high-throughput assays for serosurveillance. A) Positivity defined by qualification as CCP, coronavirus disease convalescent plasma donor (excluding purposely selected serosilent specimens). B) Positivity defined by neutralizing activity measured by Broad plaque reduction neutralization test. C) Positivity defined by operational standard (>3 binding antibody assays reactive). Dots indicate point estimates, and bars indicate Wilson score 95% CIs. Ortho VITROS IgG S assay is included only in panel B because the assay required use of serum for testing; thus, only specimens with available serum and neutralizing data were tested. Ab, antibody; Ag, antigen; N, nucleocapsid; RBD, receptor binding domain; PRNT, plaque reduction neutralization test; S, spike protein.