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Volume 28, Number 4—April 2022

Diminishing Immune Responses against Variants of Concern in Dialysis Patients 4 Months after SARS-CoV-2 mRNA Vaccination

Alex Dulovic1, Monika Strengert1, Gema Morillas Ramos1, Matthias Becker, Johanna Griesbaum, Daniel Junker, Karsten Lürken, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Anne Cossmann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause2Comments to Author , Nicole Schneiderhan-Marra2Comments to Author , and Georg M.N. Behrens2Comments to Author 
Author affiliations: University of Tübingen Natural and Medical Sciences Institute, Reutlingen, Germany (A. Dulovic, M. Becker, J. Griesbaum, D. Junker, P.D. Kaiser, B. Traenkle, U. Rothbauer, N. Schneiderhan-Marra); Helmholtz Centre for Infection Research, Braunschweig, Germany (M. Strengert, G. Krause); TWINCORE GmbH Centre for Experimental and Clinical Infection Research, Hannover, Germany (M. Strengert, G. Krause); Hannover Medical School, Hannover (G. Morillas Ramos, A. Cossmann, M.V. Stankov, A. Dopfer-Jablonka, G.M.N. Behrens); Dialysis Centre Eickenhof, Langenhagen, Germany (K. Lürken, A. Beigel, E. Wrenger, G. Lonnemann); German Centre for Infection Research, Hannover–Braunschweig, Germany (A. Dopfer-Jablonka, G. Krause, G.M.N. Behrens); University of Tübingen Pharmaceutical Biotechnology, Tübingen (U. Rothbauer); Centre for Individualized Infection Medicine, Hannover (G.M.N. Behrens)

Main Article


Characteristics of participants in a study of immune response against variants of concern in dialysis patients 4 months after SARS-CoV-2 mRNA vaccination*

Characteristic Nondialysis control group Hemodialysis group p value for difference between groups
No. (%) patients
23 (100)
76 (100)
Median age, y (IQR)
55 (14)
70.5 (18.25)
2.78 × 10−9
Sex 1.01 × 10−2
M 6 (26.09) 43 (56.58)
17 (73.91)
33 (43.42)

Median days since start of hemodialysis (IQR)
1,337 (1,686.5)
Using immunosuppressive medication
10 (13.16)
6.77 × 10−2
Underlying condition
Obesity, BMI >30‡ 4 (17.39) 16 (21.05) 8.68 × 10−1
Diabetes mellitus 0 19 (25) 7.30 × 10−3
Cardiovascular disease 0 35 (46.05) 2.93 × 10−5

*Values are no. (%) except as indicated. Percentages are for total group. BMI, body mass index; IQR, interquartile range; NA, not applicable; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. †p value reflects difference in male-to-female ratios between the two groups, not differences explicitly for either male or female persons. ‡BMI for 1 person was not known.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

Page created: December 28, 2021
Page updated: March 19, 2022
Page reviewed: March 19, 2022
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