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Volume 28, Number 6—June 2022
Dispatch

Burkholderia pseudomallei in Environment of Adolescent Siblings with Melioidosis, Kerala, India, 2019

Praveena Bhaskaran, Vinitha Prasad, Anusha Gopinathan, Tushar Shaw, Suchitra Sivadas, Chandrasekhar Jayakumar, Soumi Chowdhury, Aparna Dravid, Chiranjay Mukhopadhyay, and Anil KumarComments to Author 
Author affiliations: Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India (P. Bhaskaran, V. Prasad, S. Sivadas, C. Jayakumar, A. Kumar); SRM Medical College Hospital and Research Centre, Chennai, India (A. Gopinathan); Ramaiah University of Applied Sciences, Bangalore, India (T. Shaw); Manipal Academy of Higher Education, Manipal, India (T. Shaw, S. Chowdhury, A. Dravid, C. Mukhopadhyay)

Main Article

Table

Clinical and laboratory characteristics of 2 siblings with melioidosis, Kerala, India, 2019*

Characteristic Patient 1, 15-year-old boy† Patient 2, 12-year-old boy‡
Clinical
Comorbidities None None
Date of admission Jul 1 Aug 8
Clinical condition
 Pneumonia, ARDS, septic shock
 Fever, sore throat, cervical lymphadenopathy
Laboratory
Hemoglobin (ref 12.7–17.7), g/dL 13 13.4
Total leukocytes (ref 5,500–15,500), cells/μL 3,190 14,260
Neutrophils (ref 55–70), % 90 73.1
Thrombocytes (ref 150–400), K/µL 100 223
AST (ref 0–51), IU/L 139.4 21.2
ALT (ref 0–39), IU/L 98 16.3
Creatinine (ref 0.4–1.06), mg/dL 26.4/1.13 0.54
BUN (ref 5–20), mg/dl 26.4 14.3
Ferritin (ref 36–311), ng/mL 5,448 1374
Procalcitonin (refR <0.5), ng/mL 6.8 0.36
C-reactive protein (ref <10), mg/L) 319 16.86
Culture (source) Burkholderia pseudomallei (blood, skin lesions) B. pseudomallei (lymph node, throat swab)
Blood PCR
 Positive for Burkholderia mallei/B. pseudomallei
 Not detected
Diagnosis (manifestations)
 Melioidosis (pneumonia, ARDS, sepsis)
 Melioidosis (lymphadenitis)
Treatment
 Piperacillin/tazobactam, meropenem, vancomycin
 Ceftazidime, meropenem, trimethoprim/sulfamethoxazole
Outcome Died Jul 2 Discharged Sep 20

*ARDS, acute respiratory distress syndrome; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ref, reference range.

Main Article

Page created: March 23, 2022
Page updated: May 22, 2022
Page reviewed: May 22, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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