Volume 28, Number 8—August 2022
Research
Increasing and More Commonly Refractory Mycobacterium avium Pulmonary Disease, Toronto, Ontario, Canada
, Sarah K. Brode, Mahtab Mehrabi, and Theodore K. Marras
Table 4
Outcomes of treatment in patients with Mycobacterium avium and M. xenopi pulmonary disease, Toronto, Ontario, Canada*
| Outcome | M. avium |
M. xenopi |
|||||
|---|---|---|---|---|---|---|---|
| Early period, n = 82 | Late period, n = 138 | p value | Early period, n = 24 | Late period, n = 8 | p value | ||
| Mean duration of follow up after treatment initiation, mo (IQR) |
31.0 (19.3–44.0) |
31.0 (18.3–39.0) |
0.23 |
28.0 (14.8–53.0) |
18.5 (12.8–25.8) |
0.32 |
|
| Culture conversion† | 32 (39.0) | 36 (26.1) | 0.05 | 16 (66.7) | 5 (62.5) | Referent | |
| Toronto-York region‡ | 29/68 (42.6) | 26/109 (23.9) | 0.01 | 14/19 (73.7) | 5/6 (83.3) | Referent | |
| Outside Toronto-York region |
3/14 (21.4) |
10/29 (34.5) |
0.49 |
2/5 (40.0) |
0/2 |
Referent |
|
| Culture reversion |
4 (12.5) |
11 (30.6) |
0.09 |
1/16 (6.25) |
0/5 |
Referent |
|
| Clinical treatment success§ | 56 (68.3) | 88 (63.8) | 0.47 | 15 (62.5) | 5 (62.5) | Referent | |
*Values are no. (%) except as indicated. Bold indicates significance. Culture reversion is presented as no. (% of patients out of those who had culture conversion). Patients with insufficient samples submitted for evaluation of culture conversion were deemed not converted. Patients with missing follow up computed tomography results were considered not clinically successful. †Overall insufficient samples: M. avium early period, 19 (23.2%); M. avium late period, 23 (16.7%); M. xenopi early period, 4 (16.7%); M. xenopi late period, 2 (25%). ‡Insufficient samples among Toronto-York region patients: M. avium early period, 12 (17.6%); M. avium late period, 16 (14.7%); M. xenopi early period, 3 (15.8%); M. xenopi late period, 0. §Missing computed tomography results: M. avium early period, 4 (5.0%); M. avium late period, 9 (6.5%); M. xenopi early period, 1 (4.2%); M. xenopi late period, 1 (12.5%).
1Current affiliation: Ziekenhuis Oost-Limburg, Genk, Belgium.