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Volume 29, Number 1—January 2023

Detection of Clade Avian Influenza A(H5N8) Virus in Cambodia, 2021

Kimberly M. Edwards, Jurre Y. Siegers, Xiaoman Wei, Ammar Aziz, Yi-Mo Deng, Sokhoun Yann, Chan Bun, Seng Bunnary, Leonard Izzard, Makara Hak, Peter Thielen, Sothyra Tum, Frank Wong, Nicola S. Lewis, Joe James, Filip Claes, Ian G. Barr, Vijaykrishna Dhanasekaran1, and Erik A Karlsson1Comments to Author 
Author affiliations: University of Hong Kong, Hong Kong, China (K.M. Edwards, X. Wei, V. Dhanasekaran); Institut Pasteur du Cambodge, Phnom Penh, Cambodia (J.Y. Siegers, S. Yann, E.A. Karlsson); Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia (A. Aziz, Y.-M. Deng, I.G. Barr); National Animal Health and Production Research Institute, Phnom Penh (C. Bun, S. Bunnary, S. Tum); Australian Center for Disease Preparedness, Geelong, Victoria, Australia (L. Izzard, F. Wong); Food and Agriculture Organization of the United Nations, Phnom Penh (M. Hak); Johns Hopkins University, Baltimore, Maryland, USA (P. Theilen); Royal Veterinary College, London, UK (N.S. Lewis, J. James); OIE/FAO International Reference Laboratory for Avian Influenza, Swine influenza and Newcastle Disease, Weybridge, UK (N.S. Lewis); Food and Agriculture Organization of the United Nations, Bangkok, Thailand (F. Claes)

Main Article

Table 1

Amino acid mutations in hemagglutinin relative to the reference strain A/Astrakhan/3212/2020 in clade avian influenza A(H5N8) viruses detected in Cambodia, 2021*

H5 clade strain HA amino acid position†
188 192 273 276 312 339
A/Astrakhan/3212/2020 (CVV)‡ A T E H N I
A/duck/Cambodia/f6T241D4/2021 I K N S
A/duck/Cambodia/f4K241D3_C/2021 V I N
A/duck/Cambodia/f4K241D4/2021 V I N
A/duck/Cambodia/f1PPOreu241D3_C/2021 I N K
A/duck/Cambodia/f1PPChba241D6/2021 I N

*Blank cells indicate no mutation. HA, hemagglutinin. †Amino acids were numbered according to the hemagglutinin H3 numbering system. 
‡Candidate vaccine virus reference strain (GISAID accession no. EPI_ISL_1038924;

Main Article

1These authors contributed equally to this article.

Page created: November 18, 2022
Page updated: December 22, 2022
Page reviewed: December 22, 2022
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