Volume 29, Number 10—October 2023
Research
Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis
Table 3
Group by sexual practice | HIV/PrEP status | Signs on examination | Mucosal PCR sites (value if positive†) |
Serologic test results |
Previous serologic test results (RPR titer if reactive) | Staging of syphilis | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Oral cavity | Vagina | Anus | Lesion PCR sites (value if positive†) | Current RPR titer | Previous syphilis serologic test | ||||||
Woman | Neg | Oral ulcers | + (36) | – | – | 1:64 | 24 mo | Negative | Primary | ||
MSM | Neg | Tender anal ulcers | – | NA | + (30) | 1:16 | 3 wks | 1:1 | Primary | ||
MSM | HIV | Torso and hand rash | + (31) | NA | + (30) | 1:64 | 5 mo | Nonreactive | Secondary | ||
MSM | PrEP | Torso rash, penis and perianal rash | + (34) | NA | + (30) | 1:128 | 2 mo | Nonreactive | Secondary | ||
MSM‡ | Neg | Maculopapular rash on torso and soles | – | NA | + (26) | 1:256 | 12 mo | Unknown | Secondary | ||
MSM‡ | Neg | Ulcer on tongue, scrotal rash | + (32) | NA | + (36) | Tongue, + (30); scrotum, + (39) | 1:32 | 26 mo | Unknown | Primary | |
MSM | HIV | Penile ulcer | + (34) | NA | + (40) | Penis, + (34) | 1:128 | 4 mo | Negative | Primary | |
Bisexual man | Neg | Penile ulcers | – | NA | – | Penis, + (38) | 1:32 | 15 mo | Negative | Primary | |
MSM | HIV | Penile ulcers, torso rash | – | NA | – | Penis, + (36) | 1:64 | 12 mo | Negative | Secondary | |
MSM | HIV | Palms and feet rash, ulcers on penis, and nodules on scrotum | – | NA | – | Penis, + (36) scrotum, –; palms, –; soles, – | 1:128 | 16 mo | 1:1 | Secondary |
*MSM, men who have sex with men; NA, not applicable; ND, not done; neg, HIV negative and not taking PrEP; PrEP, preexposure prophylaxis for HIV; RPR, rapid plasma reagin; woman, heterosexual woman; –, negative by T. pallidum PCR; +, positive by T. pallidum PCR. †Cycle threshold value of T. pallidum PCR. ‡These 2 patients had syphilis treated at other clinics previously, but the exact RPR at that time is unknown.
1These senior authors contributed equally to this article.
Page created: August 31, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
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