Volume 29, Number 3—March 2023
CME ACTIVITY - Research
Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021
Koh Shinohara, Kazunori Murase, Yasuhiro Tsuchido, Taro Noguchi, Satomi Yukawa, Masaki Yamamoto, Yasufumi Matsumura, Ichiro Nakagawa, and Miki Nagao
Table 1
Characteristics of 133 patients with Streptococcus dysgalactiae subspecies equisimilis bacteremia, Japan, 2005–2021*
| Characteristic | Value |
|---|---|
| Median age, y (IQR) |
81.0 (72.0–88.0) |
| Age group, y | |
| <30 | 1 (0.8) |
| 30–39 | 4 (3.0) |
| 40–49 | 5 (3.6) |
| 50–59 | 6 (4.5) |
| 60–69 | 12 (9.0) |
| 70–79 | 29 (21.8) |
| 80–89 | 50 (37.6) |
| >90 |
26 (19.5) |
| Sex | |
| M | 72 (54.1) |
| F |
61 (45.9) |
| Medical history | |
| No underlying conditions | 15 (11.3) |
| Solid organ tumor† | 36 (27.1) |
| History of surgery, n = 36 | 15 (41.7) |
| Active malignancy, n = 36‡ | 22 (61.1) |
| Metastasis, n = 36 | 10 (27.8) |
| Hematologic malignancy | 6 (4.5) |
| Hematopoietic stem cell transplant, n = 6 | |
| Cardiovascular disease | 21 (15.8) |
| Cerebral artery diseases | 38 (28.6) |
| Chronic kidney diseases | 27 (20.3) |
| Diabetes mellitus | 22 (16.5) |
| Dementia | 31 (23.3) |
| Collagen diseases | 8 (6.0) |
| Chronic lung diseases | 7 (5.3) |
| HIV | 0 |
| Chemotherapy | 12 (9.0) |
| Immune suppressive therapy | 6 (4.5) |
| Neutropenia, neutrophil count <500 cells/µL | 5 (3.8) |
*Values are no. (%) except as indicated. For patients with multiple episodes, variables for the first episode are described. †Ten patients with prostate cancer; 8 with cervical cancer; 7 with colon, rectal, or anal cancer; 3 with lung cancer; 2 with stomach cancer; 2 with endometrial cancer; 2 with bladder cancer; 2 with breast cancer; and 1 with cancer categorized as other (esophageal cancer, ovarian cancer, pharyngeal cancer, salivary gland cancer, vaginal cancer, and extramammary Paget’s disease), including duplicates. ‡Treated within 5 years.
Page created: February 23, 2023
Page updated: February 23, 2023
Page reviewed: February 23, 2023
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