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Volume 29, Number 3—March 2023
CME ACTIVITY - Research

Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021

Koh Shinohara, Kazunori Murase, Yasuhiro Tsuchido, Taro Noguchi, Satomi Yukawa, Masaki Yamamoto, Yasufumi Matsumura, Ichiro Nakagawa, and Miki NagaoComments to Author 
Author affiliation: Kyoto University Graduate School of Medicine, Kyoto, Japan

Main Article

Table 1

Characteristics of 133 patients with Streptococcus dysgalactiae subspecies equisimilis bacteremia, Japan, 2005–2021*

Characteristic Value
Median age, y (IQR)
81.0 (72.0–88.0)
Age group, y
<30 1 (0.8)
30–39 4 (3.0)
40–49 5 (3.6)
50–59 6 (4.5)
60–69 12 (9.0)
70–79 29 (21.8)
80–89 50 (37.6)
>90
26 (19.5)
Sex
M 72 (54.1)
F
61 (45.9)
Medical history
No underlying conditions 15 (11.3)
Solid organ tumor† 36 (27.1)
History of surgery, n = 36 15 (41.7)
Active malignancy, n = 36‡ 22 (61.1)
Metastasis, n = 36 10 (27.8)
Hematologic malignancy 6 (4.5)
Hematopoietic stem cell transplant, n = 6
Cardiovascular disease 21 (15.8)
Cerebral artery diseases 38 (28.6)
Chronic kidney diseases 27 (20.3)
Diabetes mellitus 22 (16.5)
Dementia 31 (23.3)
Collagen diseases 8 (6.0)
Chronic lung diseases 7 (5.3)
HIV 0
Chemotherapy 12 (9.0)
Immune suppressive therapy 6 (4.5)
Neutropenia, neutrophil count <500 cells/µL 5 (3.8)

*Values are no. (%) except as indicated. For patients with multiple episodes, variables for the first episode are described. †Ten patients with prostate cancer; 8 with cervical cancer; 7 with colon, rectal, or anal cancer; 3 with lung cancer; 2 with stomach cancer; 2 with endometrial cancer; 2 with bladder cancer; 2 with breast cancer; and 1 with cancer categorized as other (esophageal cancer, ovarian cancer, pharyngeal cancer, salivary gland cancer, vaginal cancer, and extramammary Paget’s disease), including duplicates. ‡Treated within 5 years.

Main Article

Page created: February 23, 2023
Page updated: February 23, 2023
Page reviewed: February 23, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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