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Volume 29, Number 4—April 2023
Research Letter

Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA

Marjorie Farrington1, Jamie Elenz, Matthew Ginsberg, Charles Y. Chiu, Steve Miller, and Scott F. PangonisComments to Author 
Author affiliations: Children’s Hospital Medical Center of Akron, Akron, Ohio, USA (M. Farrington, M. Ginsberg, S.F Pangonis); Columbiana County Health District, Lisbon, Ohio, USA (J. Elenz); University of California, San Francisco, California, USA (C.Y. Chiu, S. Miller)

Main Article

Table

Test results for infectious and noninfectious causes of meningitis and encephalitis in study of Powassan virus infection detected by metagenomic next-generation sequencing, Ohio, USA*

Tests
 Results
Infectious causes
CSF meningitis encephalitis PCR panel† No organisms detected

*CSF, cerebrospinal fluid; EBV, Epstein-Barr virus. †BIOFIRE FILMARRAY Meningitis/Encephalitis PCR panel (bioMérieux, https://www.biomerieux-diagnostics.com). Panel included Streptococcus pneumoniae, S. agalactiae, Haemophilus influenzae, Neisseria meningitidis, Listeria monocytogenes, Escherichia coli, Cryptococcus neoformans/gattii, varicella-zoster virus, cytomegalovirus, herpes simplex virus types 1 and 2, Enterovirus, human herpesvirus 6, and Parechovirus. ‡Acute and convalescent serum samples were sent to Mayo Clinic Laboratories (https://www.mayocliniclabs.com) for arbovirus and EBV analysis. Arbovirus panel included La Crosse encephalitis virus, eastern equine encephalitis virus, western equine encephalitis virus, West Nile encephalitis virus, and St. Louis encephalitis virus.

Main Article

1Current affiliation: St. Louis Children’s Hospital, St. Louis, Missouri, USA.

Page created: January 28, 2023
Page updated: March 21, 2023
Page reviewed: March 21, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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