Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States
Sichen Liu
1, Suraj Kannan
1, Monica Meeks, Sandra Sanchez, Kyle W. Girone, James C. Broyhill, Roosecelis Brasil Martines, Joshua Bernick, Lori Flammia, Julia Murphy, Susan L. Hills, Kristen L. Burkhalter, Janeen J. Laven, David Gaines, and Christopher J. Hoffmann
Author affiliations: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA (S. Liu); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (S. Kannan, M. Meeks, S. Sanchez, C.J. Hoffman); Virginia Department of Health, Richmond, Virginia, USA (K.W. Girone, J.C. Broyhill, J. Bernick, L. Flammia, J. Murphy, D. Gaines); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.B. Martines); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (S.L. Hills, K.L. Burkhalter, J.J. Laven)
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Figure 1
Figure 1. Postmortem autopsy findings in a fatal case of heartland virus disease acquired in the mid-Atlantic region, United States. A) Hematoxylin and eosin stain of patient accessory spleen; arrow indicates congestion with hemophagocytic histiocytes. Scale bar indicates 50 μm. B) Hematoxylin and eosin stain showing pulmonary hyperinflammation, including pleural thickening and adhesions, and pulmonary fibrosis, edema, and calcifications. Scale bar indicates 125 μm.
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Page created: February 17, 2023
Page updated: April 19, 2023
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