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Volume 29, Number 5—May 2023
Dispatch

Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 20201

Xiangyun Zhi, Ho Kwong Li, Hanqi Li, Zuzanna Loboda, Samson Charles, Ana Vieira, Kristin Huse, Elita Jauneikaite, Lucy Reeves, Kai Yi Mok, Juliana Coelho, Theresa Lamagni, and Shiranee SriskandanComments to Author 
Author affiliations: Imperial College London, London, UK (X. Zhi, H.K. Li, H. Li, Z. Loboda, S. Charles, A. Vieira, K. Huse, E. Jauneikaite, L. Reeves, K.Y. Mok, S. Sriskandan); United Kingdom Health Security Agency, London (J. Coelho, T. Lamagni)

Main Article

Figure 2

Prevalence of M1UK and M1global Streptococcus pyogenes lineages over time in study of emerging invasive group A Streptococcus M1UK lineage detected by allele-specific PCR, England, 2020. We determined percentages of emm1 isolates in England that belonged to M1UK or M1global lineages by using all available emm1 S. pyogenes genome sequences for 2007–2016 (4) and all available invasive isolates from 2020 that we tested by allele-specific PCR. Numbers on graph indicate number of isolates assigned as M1UK/total number sequenced for each year. Graph was adapted and updated from data previously described (4).

Figure 2. Prevalence of M1UK and M1global Streptococcus pyogenes lineages over time in study of emerging invasive group A Streptococcus M1UK lineage detected by allele-specific PCR, England, 2020. We determined percentages of emm1 isolates in England that belonged to M1UK or M1global lineages by using all available emm1 S. pyogenes genome sequences for 2007–2016 (4) and all available invasive isolates from 2020 that we tested by allele-specific PCR. Numbers on graph indicate number of isolates assigned as M1UK/total number sequenced for each year. Graph was adapted and updated from data previously described (4).

Main Article

References
  1. World Health Organization. Increase in invasive group A streptococcal infections among children in Europe, including fatalities [cited 2022 Dec 14]. https://www.who.int/europe/news/item/12-12-2022-increase-in-invasive-group-a-streptococcal-infections-among-children-in-europe--including-fatalities
  2. Turner  CE, Pyzio  M, Song  B, Lamagni  T, Meltzer  M, Chow  JY, et al. Scarlet fever upsurge in England and molecular-genetic analysis in north-west London, 2014. Emerg Infect Dis. 2016;22:10758. DOIPubMedGoogle Scholar
  3. Lamagni  T, Guy  R, Chand  M, Henderson  KL, Chalker  V, Lewis  J, et al. Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study. Lancet Infect Dis. 2018;18:1807. DOIPubMedGoogle Scholar
  4. Lynskey  NN, Jauneikaite  E, Li  HK, Zhi  X, Turner  CE, Mosavie  M, et al. Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study. Lancet Infect Dis. 2019;19:120918. DOIPubMedGoogle Scholar
  5. Nasser  W, Beres  SB, Olsen  RJ, Dean  MA, Rice  KA, Long  SW, et al. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A. 2014;111:E176876. DOIPubMedGoogle Scholar
  6. Sumby  P, Porcella  SF, Madrigal  AG, Barbian  KD, Virtaneva  K, Ricklefs  SM, et al. Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. J Infect Dis. 2005;192:77182. DOIPubMedGoogle Scholar
  7. Rümke  LW, de Gier  B, Vestjens  SMT, van der Ende  A, van Sorge  NM, Vlaminckx  BJM, et al. Dominance of M1UK clade among Dutch M1 Streptococcus pyogenes. Lancet Infect Dis. 2020;20:53940. DOIPubMedGoogle Scholar
  8. Demczuk  W, Martin  I, Domingo  FR, MacDonald  D, Mulvey  MR. Identification of Streptococcus pyogenes M1UK clone in Canada. Lancet Infect Dis. 2019;19:12845. DOIPubMedGoogle Scholar
  9. Li  Y, Nanduri  SA, Van Beneden  CA, Beall  BW. M1UK lineage in invasive group A streptococcus isolates from the USA. Lancet Infect Dis. 2020;20:5389. DOIPubMedGoogle Scholar
  10. Davies  MR, Keller  N, Brouwer  S, Jespersen  MG, Cork  AJ, Hayes  AJ, et al. Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nat Commun. 2023;14:1051. DOIPubMedGoogle Scholar
  11. Turner  CE, Abbott  J, Lamagni  T, Holden  MTG, David  S, Jones  MD, et al. Emergence of a new highly successful acapsular group A Streptococcus clade of genotype emm89 in the United Kingdom. MBio. 2015;6:e00622. DOIPubMedGoogle Scholar
  12. Al-Shahib  A, Underwood  A, Afshar  B, Turner  CE, Lamagni  T, Sriskandan  S, et al. Emergence of a novel lineage containing a prophage in emm/M3 group A Streptococcus associated with upsurge in invasive disease in the UK. Microb Genom. 2016;2:e000059.PubMedGoogle Scholar
  13. UK Health Security Agency. Group A streptococcal infections: second update on seasonal activity in England 2022 to 2023 [cited 2022 Dec 16]. https://www.gov.uk/government/publications/group-a-streptococcal-infections-activity-during-the-2022-to-2023-season/group-a-streptococcal-infections-second-update-on-seasonal-activity-in-england-2022-to-2023
  14. Cordery  R, Purba  AK, Begum  L, Mills  E, Mosavie  M, Vieira  A, et al. Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK. Lancet Microbe. 2022;3:e36675. DOIPubMedGoogle Scholar
  15. Nelson  GE, Pondo  T, Toews  KA, Farley  MM, Lindegren  ML, Lynfield  R, et al. Epidemiology of invasive group A streptococcal infections in the United States, 2005–2012. Clin Infect Dis. 2016;63:47886. DOIPubMedGoogle Scholar

Main Article

1Data from this study were presented at the 21st Lancefield International Symposium on Streptococci and Streptococcal Diseases; Stockholm, Sweden; June 7–10, 2022.

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Page updated: April 19, 2023
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