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Volume 29, Number 5—May 2023
Dispatch

Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions

Madeleine de le Roi, Christina Puff, Peter Wohlsein, Florian Pfaff, Martin Beer, Wolfgang Baumgärtner, and Dennis RubbenstrothComments to Author 
Author affiliations: University of Veterinary Medicine Hannover Foundation, Hannover, Germany (M. de le Roi, C. Puff, P. Wohlsein, W. Baumgärtner); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (F. Pfaff, M. Beer, D. Rubbenstroth)

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Figure 1

Histopathologic, immunohistochemical, and in situ hybridization findings in the cerebrum of a lion tested positive for rustrela virus (RusV) by quantitative reverse transcription PCR. A) Histopathologic analysis of cerebral sample from lion 3 indicated lymphohistiocytic meningoencephalitis and vasculitis. B) Immunohistochemistry analysis showed RusV antigen in cortical neurons and their processes. Cytoplasmic granular immunoreactivity is visible (inset). C) In situ hybridization revealed RusV RNA in cortical neurons; we observed cytoplasmic granular-positive signal (inset). Scale bars indicate 50 µm.

Figure 1. Histopathologic, immunohistochemical, and in situ hybridization findings in the cerebrum of a lion tested positive for rustrela virus (RusV) by quantitative reverse transcription PCR. A) Histopathologic analysis of cerebral sample from lion 3 indicated lymphohistiocytic meningoencephalitis and vasculitis. B) Immunohistochemistry analysis showed RusV antigen in cortical neurons and their processes. Cytoplasmic granular immunoreactivity is visible (inset). C) In situ hybridization revealed RusV RNA in cortical neurons; we observed cytoplasmic granular-positive signal (inset). Scale bars indicate 50 µm.

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Page created: April 04, 2023
Page updated: April 19, 2023
Page reviewed: April 19, 2023
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