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Volume 29, Number 6—June 2023
Dispatch

Tanapox, South Africa, 2022

Monica Birkhead1Comments to Author , Wayne Grayson1, Antoinette Grobbelaar, Veerle Msimang, Naazneen Moolla, Angela Mathee, Lucille Blumberg, Terry Marshall, Daniel Morobadi, Mirjana Popara, and Jacqueline Weyer
Author affiliations: National Institute for Communicable Diseases, Johannesburg, South Africa (M. Birkhead, A. Grobbelaar, V. Msimang, N. Moolla, L. Blumberg, J. Weyer); Ampath Laboratories, Centurion, South Africa (W. Grayson, T. Marshall, D. Morobadi); University of the Witwatersrand, Johannesburg (W. Grayson, J. Weyer); South African Medical Research Council, Cape Town, South Africa (A. Mathee); University of Johannesburg, Johannesburg (A. Mathee); University of Pretoria, Pretoria, South Africa (N. Moolla, L. Blumberg, J. Weyer); Right to Care, Johannesburg (L. Blumberg); University of the Free State, Bloemfontein, South Africa (D. Morobadi); Mediclinic, Sandton, South Africa (M. Popara)

Main Article

Figure 2

Diagnostic light and electron microscopy of tanapox lesion biopsies from a case-patient, South Africa, 2022. A) High-power photomicrograph of initial skin biopsy, showing prominent vacuolation of epidermal keratinocytes, granular intracytoplasmic inclusions, and intranuclear pseudoinclusions. Hematoxylin and eosin stain; original magnification ×400. B) Low-power photomicrograph of initial skin biopsy, showing a superficially eroded hyperplastic epidermis, with cytoplasmic pallor and a dense underlying superficial dermal lymphoid infiltrate. Hematoxylin and eosin stain; original magnification ×40. C) Negatively stained tanapox virus virion with surface tubules evident beneath the remains of the surrounding membrane. Virion dimensions were 159–327 nm × 186–289 nm. Scale bar indicates 100 nm.

Figure 2. Diagnostic light and electron microscopy of tanapox lesion biopsies from a case-patient, South Africa, 2022. A) High-power photomicrograph of initial skin biopsy, showing prominent vacuolation of epidermal keratinocytes, granular intracytoplasmic inclusions, and intranuclear pseudoinclusions. Hematoxylin and eosin stain; original magnification ×400. B) Low-power photomicrograph of initial skin biopsy, showing a superficially eroded hyperplastic epidermis, with cytoplasmic pallor and a dense underlying superficial dermal lymphoid infiltrate. Hematoxylin and eosin stain; original magnification ×40. C) Negatively stained tanapox virus virion with surface tubules evident beneath the remains of the surrounding membrane. Virion dimensions were 159–327 nm × 186–289 nm. Scale bar indicates 100 nm.

Main Article

1These first authors contributed equally to this article.

Page created: March 28, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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